| Ontology | CARD's Antibiotic Resistance Ontology | ||||||||||
| Accession | ARO:3000797 | ||||||||||
| Definition | MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes. | ||||||||||
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump | ||||||||||
| Drug Class | aminoglycoside antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic, cephalosporin, penicillin beta-lactam | ||||||||||
| Resistance Mechanism | antibiotic efflux | ||||||||||
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance | ||||||||||
| CARD:Epi text mining of PubMed up to 2021 (top ten associations if supported by more than one publication) |
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| Classification | 16 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + antibiotic mixture + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + gentamicin [Antibiotic] + phenicol antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + beta-lactam antibiotic + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] | ||||||||||
| Parent Term(s) | 12 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic gentamicin C [Antibiotic] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class penicillin beta-lactam [Drug Class] + confers_resistance_to_antibiotic novobiocin [Antibiotic] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic ofloxacin [Antibiotic] | ||||||||||
| Sub-Term(s) | 4 ontology terms | Show + MexC periplasmic_adaptor_protein_of + MexD inner_membrane_protein_of + OprJ outer_membrane_protein_of + NfxB with mutations conferring antibiotic resistance derepresses | ||||||||||
| Publications | Srikumar R, et al. 1998. Antimicrob Agents Chemother 42(1): 65-71. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. (PMID 9449262) Lorusso AB, et al. 2022. Int J Mol Sci 23(24): Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa. (PMID 36555423) Jeannot K, et al. 2008. Antimicrob Agents Chemother 52(7):2455-62 Resistance and virulence of Pseudomonas aeruginosa clinical strains overproducing the MexCD-OprJ efflux pump. (PMID 18474583) Masuda N, et al. 1996. Antimicrob. Agents Chemother. 40(4):909-13 Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa. (PMID 8849250) |
| Curator | Description | Most Recent Edit |
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