| Accession | ARO:3000797 |
| Definition | MexCD-OprJ is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexC is the membrane fusion protein; MexD is the inner membrane transporter; and OprJ is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, and macrolides. MexCD-OprJ is typically quiescent in wild-type cells, with expression following mutation of the nfxB gene that is divergently transcribed from the mexCD-oprJ operon and encodes a repressor of mexCD-oprJ expression. Expression of mexCD–oprJ is controlled by a single known regulator, the NfxB repressor encoded by the nfxB gene, which is transcribed divergently from the efflux genes. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | phenicol antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, macrolide antibiotic, fluoroquinolone antibiotic, cephalosporin, penam |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + phenicol antibiotic [Drug Class] + cephem + diaminopyrimidine antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] |
| Parent Term(s) | 9 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_antibiotic novobiocin [Antibiotic] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] |
| Sub-Term(s) | 8 ontology terms | Show + MexC part_of + MexD part_of + OprJ part_of + NfxB regulates + Type A NfxB regulates + Type B NfxB regulates + MexCD-OprJ with type A NfxB mutation + MexCD-OprJ with type B NfxB mutation |
| Publications | Srikumar R, et al. 1998. Antimicrob Agents Chemother 42(1): 65-71. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. (PMID 9449262) |