MexCD-OprJ with type B NfxB mutation

Accession ARO:3004062
DefinitionMexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminocoumarin antibiotic, diaminopyrimidine antibiotic, phenicol antibiotic, tetracycline antibiotic, cephalosporin, aminoglycoside antibiotic, penam, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification23 ontology terms | Show
Parent Term(s)6 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic gentamicin C [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic ofloxacin [Antibiotic]
+ MexCD-OprJ
Sub-Term(s)
4 ontology terms | Show
+ MexC part_of
+ MexD part_of
+ OprJ part_of
+ Type B NfxB part_of
Publications

Masuda N, et al. 1996. Antimicrob. Agents Chemother. 40(4):909-13 Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa. (PMID 8849250)

Resistomes

Prevalence of MexCD-OprJ with type B NfxB mutation among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MexCD–OprJ with type B NfxB mutation

Model Description: MexCD-OprJ with Type B NfxB mutions are more resistant to tetracycline and chloramphenicol, as well as ofloxacin, erythromycin, and the new zwitterionic cephems, than was PAO1, and they are four to eight times more susceptible to carbenicillin, sulbenicillin, imipenem, panipenem, biapenem, moxalactam, aztreonam, gentamicin, and kanamycin than PAO1.

OprJMexCMexDType B NfxB