| Ontology | CARD's Antibiotic Resistance Ontology | ||||||||||
| Accession | ARO:3000820 | ||||||||||
| Definition | NfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB. | ||||||||||
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump, antibiotic efflux regulatory protein | ||||||||||
| Drug Class | aminoglycoside antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic, penicillin beta-lactam, cephalosporin | ||||||||||
| Resistance Mechanism | antibiotic efflux | ||||||||||
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance | ||||||||||
| Efflux Regulator | protein(s) or two-component regulatory system modulating antibiotic efflux | ||||||||||
| CARD:Epi text mining of PubMed up to 2021 (top ten associations if supported by more than one publication) |
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| Classification | 27 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + antibiotic mixture + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + gentamicin [Antibiotic] + phenicol antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + beta-lactam antibiotic + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + ofloxacin [Antibiotic] + protein(s) or two-component regulatory system modulating antibiotic efflux [Efflux Regulator] + chloramphenicol [Antibiotic] + trimethoprim [Antibiotic] + novobiocin [Antibiotic] + penicillin beta-lactam [Drug Class] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + tetracycline [Antibiotic] + cephalosporin [Drug Class] + gentamicin C [Antibiotic] + erythromycin [Antibiotic] | ||||||||||
| Parent Term(s) | 2 ontology terms | Show | ||||||||||
| Sub-Term(s) | 2 ontology terms | Show | ||||||||||
| Publications | Poole K, et al. 1996. Mol Microbiol 21(4): 713-724. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. (PMID 8878035) Higgins PG, et al. 2003. Int. J. Antimicrob. Agents 21(5):409-13 Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa. (PMID 12727072) Purssell A, et al. 2013. Microbiology (Reading, Engl.) 159(Pt 10):2058-73 Functional characterization of the NfxB repressor of the mexCD-oprJ multidrug efflux operon of Pseudomonas aeruginosa. (PMID 23924707) Okazaki T, et al. 1992. FEMS Microbiol. Lett. 76(1-2):197-202 Cloning and nucleotide sequence of the Pseudomonas aeruginosa nfxB gene, conferring resistance to new quinolones. (PMID 1330820) |
| Curator | Description | Most Recent Edit |
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