Accession ARO:3000820
DefinitionNfxB is a repressor of the efflux pump mexCD-oprJ and itself (NfxB binds upstream of the nfxB gene and negatively regulates its own expression). Increased expression of MexCD–OprJ brought about by mutations in NfxB.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classaminocoumarin antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic, tetracycline antibiotic, cephalosporin, fluoroquinolone antibiotic, macrolide antibiotic, penam
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification21 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show

Poole K, et al. 1996. Mol Microbiol 21(4): 713-724. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa. (PMID 8878035)

Higgins PG, et al. 2003. Int. J. Antimicrob. Agents 21(5):409-13 Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa. (PMID 12727072)

Purssell A, et al. 2013. Microbiology (Reading, Engl.) 159(Pt 10):2058-73 Functional characterization of the NfxB repressor of the mexCD-oprJ multidrug efflux operon of Pseudomonas aeruginosa. (PMID 23924707)

Okazaki T, et al. 1992. FEMS Microbiol. Lett. 76(1-2):197-202 Cloning and nucleotide sequence of the Pseudomonas aeruginosa nfxB gene, conferring resistance to new quinolones. (PMID 1330820)