| Accession | ARO:3004061 |
| CARD Short Name | Paer_NfxBa_MULT |
| Definition | MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | aminocoumarin antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic, cephalosporin, penam |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 21 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + beta-lactam antibiotic + determinant of antibiotic resistance + aminocoumarin antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + diaminopyrimidine antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + cephem + tetracycline antibiotic [Drug Class] + trimethoprim [Antibiotic] + tetracycline [Antibiotic] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + chloramphenicol [Antibiotic] + novobiocin [Antibiotic] + cephalosporin [Drug Class] + penam [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + MexCD-OprJ + confers_resistance_to_antibiotic ofloxacin [Antibiotic] + confers_resistance_to_antibiotic erythromycin [Antibiotic] |
| Sub-Term(s) | 4 ontology terms | Show |
| Publications | Masuda N, et al. 1996. Antimicrob. Agents Chemother. 40(4):909-13 Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa. (PMID 8849250) |
Prevalence of MexCD-OprJ with type A NfxB mutation among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 381 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: MexCD-OprJ with type A NfxB mutation
Model Description: MexCD–OprJ with type A NfxB phenotype are four to eight times more resistant to ofloxacin, erythromycin, and new zwitterionic cephems, i.e., cefpirome, cefclidin, cefozopran, and cefoselis, than the parent strain, PAO1.
OprJMexCMexDType A NfxB