rsmA

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Accession ARO:3005069
Synonym(s)csrA
CARD Short NamersmA
DefinitionrsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classdiaminopyrimidine antibiotic, phenicol antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesPseudomonas aeruginosag+wgs, Pseudomonas fluorescensg, Pseudomonas stutzeriwgs
Resistomes with Sequence VariantsAeromonas enteropelogenesg+wgs, Aeromonas hydrophilag+wgs, Aeromonas veroniig+wgs, Bacillus subtiliswgs, Bacillus velezensiswgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Cronobacter condimentig+wgs, Cronobacter dublinensisg+wgs, Cronobacter malonaticusg+wgs, Cronobacter sakazakiig+wgs, Cronobacter turicensiswgs, Cronobacter universalisg+wgs, Edwardsiella tardag+wgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenusg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Enterococcus faecaliswgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatag+wgs, Leminorella grimontiiwgs, Luteibacter pinisolig, Morganella morganiig+wgs, Pectobacterium parmentierig+wgs, Photobacterium profundumg, Photorhabdus asymbioticag+wgs, Plesiomonas shigelloidesg+wgs, Proteus columbaeg+wgs, Proteus mirabilisg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Providencia alcalifaciensg+p+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensg, Pseudomonas mendocinag+wgs, Pseudomonas stutzerig+wgs, Pseudomonas syringaewgs, Raoultella planticolag+wgs, Salmonella bongorig+wgs, Salmonella entericag+p+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Serratia odoriferag+wgs, Serratia rubidaeag+wgs, Shewanella putrefaciensg+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Staphylococcus aureuswgs, Staphylococcus saprophyticuswgs, Vibrio parahaemolyticuswgs, Yersinia canariaeg+wgs, Yersinia enterocoliticag+wgs, Yersinia kristenseniig+wgs, Yersinia pestisg+wgs, Yersinia pseudotuberculosisg+wgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Pessi G, et al. 2001. J. Bacteriol. 183(22):6676-83 The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa. (PMID 11673439)

Mulcahy H, et al. 2006. Infect. Immun. 74(5):3012-5 The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system. (PMID 16622241)
Resistomes

Prevalence of rsmA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Aeromonas enteropelogenes100%0%100%0%
Aeromonas hydrophila100%0%80.65%0%
Aeromonas veronii92.73%0%65.17%0%
Bacillus subtilis0%0%0.29%0%
Bacillus velezensis0%0%0.37%0%
Citrobacter amalonaticus100%0%87.27%0%
Citrobacter freundii100%0%50.87%0%
Citrobacter koseri100%0%49.55%0%
Citrobacter portucalensis100%0%62.16%0%
Citrobacter werkmanii100%0%61.54%0%
Citrobacter youngae100%0%100%0%
Cronobacter condimenti100%0%100%0%
Cronobacter dublinensis100%0%100%0%
Cronobacter malonaticus100%0%85.45%0%
Cronobacter sakazakii100%0%92.6%0%
Cronobacter turicensis0%0%83.33%0%
Cronobacter universalis100%0%100%0%
Edwardsiella tarda100%0%93.33%0%
Enterobacter asburiae100%0%69.96%0%
Enterobacter cancerogenus100%0%100%0%
Enterobacter chengduensis100%0%84%0%
Enterobacter cloacae96.43%0.56%72.84%0%
Enterobacter hormaechei98.56%0.06%66.47%0%
Enterobacter kobei100%0%68.12%0%
Enterobacter roggenkampii100%0%61.51%0%
Enterococcus faecalis0%0%0.04%0%
Escherichia albertii100%0%62.58%0%
Escherichia coli67.89%0.03%61.82%0%
Escherichia fergusonii100%0%51.09%0%
Escherichia marmotae100%0%70.83%0%
Klebsiella aerogenes100%0%79.94%0%
Klebsiella huaxiensis100%0%66.67%0%
Klebsiella michiganensis100%0%69.41%0%
Klebsiella oxytoca100%0%74.79%0%
Klebsiella pneumoniae99.64%0.01%57.52%0%
Klebsiella quasipneumoniae99.16%0%73.68%0%
Kosakonia arachidis100%0%100%0%
Leclercia adecarboxylata100%0%60.47%0%
Leminorella grimontii0%0%85.71%0%
Luteibacter pinisoli100%0%0%0%
Morganella morganii100%0%56.44%0%
Pectobacterium parmentieri100%0%94.12%0%
Photobacterium profundum50%0%0%0%
Photorhabdus asymbiotica100%0%100%0%
Plesiomonas shigelloides87.5%0%89.66%0%
Proteus columbae100%0%100%0%
Proteus mirabilis100%0%42.9%0%
Proteus penneri100%0%100%0%
Proteus vulgaris100%0%77.78%0%
Providencia alcalifaciens90.91%4%96.55%0%
Providencia heimbachae100%0%71.43%0%
Providencia rettgeri100%0%54.14%0%
Providencia stuartii100%0%70.45%0%
Pseudomonas aeruginosa99.85%0.29%68.13%0%
Pseudomonas fluorescens2.78%0%0%0%
Pseudomonas mendocina100%0%100%0%
Pseudomonas stutzeri100%0%74.05%0%
Pseudomonas syringae0%0%0.34%0%
Raoultella planticola100%0%94.87%0%
Salmonella bongori100%0%94.74%0%
Salmonella enterica95.65%0.05%81.25%0%
Serratia liquefaciens100%0%50.79%0%
Serratia marcescens100%0.65%78.64%0%
Serratia odorifera100%0%100%0%
Serratia rubidaea100%0%90.91%0%
Shewanella putrefaciens100%0%87.5%0%
Shigella boydii100%0%97.78%0%
Shigella dysenteriae100%0%100%0%
Shigella flexneri100%0%81.99%0%
Shigella sonnei100%0%96.13%0%
Staphylococcus aureus0%0%0.01%0%
Staphylococcus saprophyticus0%0%0.7%0%
Vibrio parahaemolyticus0%0%0.05%0%
Yersinia canariae100%0%50%0%
Yersinia enterocolitica100%0%75.45%0%
Yersinia kristensenii100%0%65.71%0%
Yersinia pestis92.31%0%77.93%0%
Yersinia pseudotuberculosis100%0%98.53%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 100


>gb|AAC16242.1|+|rsmA [Pseudomonas aeruginosa]
MLILTRRVGETLMVGDDVTVTVLGVKGNQVRIGVNAPKEVAVHREEIYQRIQKEKDQEPNH


>gb|AF061757.1|+|835-1020|rsmA [Pseudomonas aeruginosa]
ATGCTGATTCTGACTCGTCGGGTCGGAGAGACCCTGATGGTAGGTGACGACGTCACCGTGACGGTACTGGGTGTCAAAGGGAACCAGGTG
CGCATCGGCGTCAACGCGCCGAAGGAAGTCGCCGTACACCGGGAGGAAATTTACCAGCGCATCCAGAAAGAGAAAGATCAAGAGCCAAAC
CATTAA