Accession | ARO:3000773 |
Definition | CmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein. |
AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
Drug Class | cephalosporin, fusidane antibiotic, macrolide antibiotic, fluoroquinolone antibiotic |
Resistance Mechanism | antibiotic efflux |
Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + determinant of antibiotic resistance + cephem + antibiotic efflux [Resistance Mechanism] + cephalosporin [Drug Class] + fusidane antibiotic [Drug Class] + macrolide antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
Parent Term(s) | 5 ontology terms | Show + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic cefotaxime [Antibiotic] + confers_resistance_to_antibiotic fusidic acid [Antibiotic] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] |
Sub-Term(s) | 4 ontology terms | Show |
Publications | Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904) Yao H, et al. 2016. MBio 7(5): Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics. (PMID 27651364) |