CmeABC

Accession ARO:3000773
DefinitionCmeABC is a multidrug efflux pump in Campylobacter jejuni. Its overexpression led to enhanced resistance to ciprofloxacin, norfloxacin, cefotaxime, fusidic acid, and erythromycin. CmeA acts as the periplasmic fusion protein, CmeB is the inner membrane transporter, and CmeC is an outer membrane protein.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, acridine dye, aminoglycoside antibiotic, fluoroquinolone antibiotic, triclosan, phenicol antibiotic, diaminopyrimidine antibiotic, carbapenem, glycylcycline, antibacterial free fatty acids, penam, cephalosporin, macrolide antibiotic, aminocoumarin antibiotic, monobactam, fusidic acid
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification24 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic cefotaxime [Antibiotic]
+ confers_resistance_to_antibiotic fusidic acid [Drug Class]
Sub-Term(s)
4 ontology terms | Show
+ cmeA part_of
+ cmeB part_of
+ cmeC part_of
+ cmeR regulates
Publications

Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904)

Yao H, et al. 2016. MBio 7(5): Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics. (PMID 27651364)