cmeC

Accession ARO:3000785
DefinitionCmeC is the outer membrane channel protein of the CmeABC multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classcephalosporin, macrolide antibiotic, fusidic acid, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesCampylobacter jejunig+wgs
Classification16 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904)

Resistomes

Prevalence of cmeC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Campylobacter coli0%0%0.95%
Campylobacter jejuni100%0%98.5%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 960


>gb|BAO79432.1|+|cmeC [Campylobacter jejuni subsp. jejuni]
MNKIISISAIASFTLLISACSLSPNLNIPEANYSIDNKLGALSWEKENNSSITKNWWKDFDDENLNKVVDLALKNNNDLKLAFIHMEQAA
AQLGIDFSSLLPKFDGSASGSRAKTAINAPSNRTGEVSYGNDFKMGLNLSYEIDLWGKYRDTYRASKSSFKASEYDYEAARLSVISNTVQ
TYFNLVNAYENENALKEAYESAKEIYRINDEKFQVGAVGEYELAQARANLESMALQYNEAKLNKENYLKALKILTSNDLNDILYKNQSYQ
VFNLKEFDIPTGISSTILLQRPDIGSSLEKLTQQNYLVGVARTAFLPSLSLTGLLGFESGDLDTLVKGGSKTWNIGGNFTLPIFHWGEIY
QNVNLAKLNKDEAFVNYQNTLITAFGEIRYALVARKTIRLQYDNAQASEQSYKRIYEIAKERYDIGEMSLQDYLEARQNWLNAAVAFNNT
KYSYANSIIDVIKAFGGGFEQSEDTSKNIKEESKNLDMSFRE


>gb|AB894099|+|4219-5697|cmeC [Campylobacter jejuni subsp. jejuni]
ATGAATAAAATAATTTCAATTAGTGCTATAGCAAGTTTTACTCTTTTGATTTCAGCTTGCTCTTTAAGTCCAAATTTAAATATTCCCGAA
GCAAACTATAGCATTGATAATAAGCTTGGAGCCTTATCTTGGGAAAAAGAAAACAATAGCTCTATCACAAAAAATTGGTGGAAAGATTTT
GATGATGAAAATTTAAATAAAGTGGTTGATTTAGCACTTAAAAATAATAATGATTTAAAACTTGCCTTCATACACATGGAACAAGCTGCT
GCTCAATTAGGTATAGATTTTAGCAGTTTGTTGCCAAAATTTGATGGTAGCGCAAGCGGTAGTCGTGCAAAAACAGCTATAAATGCTCCA
AGCAATCGAACTGGGGAAGTAAGTTACGGTAATGATTTTAAAATGGGGCTTAATTTAAGCTATGAAATCGATCTTTGGGGAAAATATCGC
GATACATATCGTGCCTCAAAATCAAGCTTTAAAGCAAGTGAGTATGATTATGAAGCTGCAAGACTTTCTGTTATTTCAAATACGGTTCAA
ACTTATTTTAATCTTGTAAATGCTTATGAAAATGAAAATGCTCTTAAAGAAGCCTATGAATCTGCAAAAGAAATTTATAGGATTAATGAT
GAAAAATTTCAAGTTGGTGCTGTAGGTGAATATGAACTTGCTCAAGCAAGAGCCAACTTAGAAAGTATGGCTTTGCAATATAATGAAGCA
AAATTAAATAAAGAAAATTACCTTAAAGCTTTAAAAATTTTAACTTCAAATGATTTAAATGACATACTTTACAAAAATCAAAGCTATCAA
GTTTTTAATCTTAAAGAATTTGACATTCCAACTGGAATTTCAAGCACCATCTTGCTTCAACGTCCAGATATTGGCTCTTCTTTAGAAAAA
TTAACTCAGCAAAATTATCTTGTTGGAGTAGCTCGCACGGCTTTCTTACCTAGCCTTTCTTTAACAGGATTATTGGGATTTGAAAGTGGG
GATTTAGATACCTTGGTTAAAGGAGGTTCTAAGACTTGGAATATAGGTGGAAACTTTACTCTGCCTATTTTTCATTGGGGTGAAATTTAC
CAAAATGTAAATTTAGCTAAGCTTAATAAAGATGAAGCTTTTGTAAATTATCAAAATACTTTGATTACTGCTTTTGGAGAAATTCGCTAT
GCTTTAGTAGCTAGAAAAACTATACGCTTACAATACGATAATGCACAAGCAAGCGAACAATCTTACAAAAGAATCTATGAAATTGCTAAA
GAACGCTATGATATAGGAGAAATGTCTTTGCAAGATTATTTAGAAGCACGTCAAAATTGGCTTAATGCTGCCGTTGCTTTTAATAATACT
AAATATTCTTATGCCAATTCCATAATAGATGTAATCAAAGCATTTGGTGGAGGATTTGAGCAAAGTGAAGATACGAGTAAAAATATAAAA
GAAGAATCAAAAAATTTAGATATGTCTTTTAGAGAATAG