fusidic acid [Drug Class]

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Accession ARO:3000759
DefinitionFusidic acid is the only commercially available fusidane, a group of steroid-like antibiotics. It is most active against Gram-positive bacteria, and acts by inhibiting elongation factor G to block protein synthesis.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
10 ontology terms | Show
+ elongation factor G targeted_by_antibiotic
+ CmeABC confers_resistance_to_antibiotic
+ fusB confers_resistance_to_antibiotic
+ FusF confers_resistance_to_antibiotic
+ fusH confers_resistance_to_antibiotic
+ fusD confers_resistance_to_antibiotic
+ fusC confers_resistance_to_antibiotic
+ fusidic acid inactivation enzyme [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistant fusA [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistant fusE [AMR Gene Family] confers_resistance_to_drug_class

Muhonen J, et al. 2008. Anal Biochem 374(1): 133-142. Interactions of fusidic acid and elongation factor G with lipid membranes. (PMID 17980694)

Drugeon HB, et al. 1994. J Antimicrob Chemother 34(6): 899-907. In-vitro antibacterial activity of fusidic acid alone and in combination with other antibiotics against methicillin-sensitive and -resistant Staphylococcus aureus. (PMID 7730233)