| Accession | ARO:3003552 |
| CARD Short Name | fusB |
| Definition | FusB encodes a 2-domain zinc-binding protein that binds the ribosomal translocase EF-G, causing it to dissociate from the ribosome. This action increases the ribosomal turnover rate and confers resistance to fusidic acid. This protein is considered a FusB-type protein. |
| AMR Gene Family | Target protecting FusB-type protein conferring resistance to Fusidic acid |
| Drug Class | fusidane antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitiswgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus haemolyticusg+p+wgs+gi, Staphylococcus hominiswgs, Staphylococcus lugdunensisg, Staphylococcus pasteurig+wgs, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs |
| Resistomes with Sequence Variants | Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitiswgs, Staphylococcus epidermidisg+p+wgs+gi, Staphylococcus haemolyticusg+p+wgs+gi, Staphylococcus hominiswgs, Staphylococcus lugdunensisg, Staphylococcus pasteurig+wgs, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic fusidic acid [Antibiotic] + Target protecting FusB-type protein conferring resistance to Fusidic acid [AMR Gene Family] |
| Publications | Cox G, et al. 2012. Proc. Natl. Acad. Sci. U.S.A. 109(6):2102-7 Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. (PMID 22308410) O'Neill AJ, et al. 2006. Mol. Microbiol. 59(2):664-76 Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus. (PMID 16390458) |
Prevalence of fusB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Staphylococcus aureus | 0.35% | 0.07% | 0.43% | 0.29% |
| Staphylococcus capitis | 0% | 0% | 8.23% | 0% |
| Staphylococcus epidermidis | 35.48% | 0.29% | 13.72% | 2.86% |
| Staphylococcus haemolyticus | 24.14% | 1.89% | 11.65% | 6.67% |
| Staphylococcus hominis | 0% | 0% | 4.88% | 0% |
| Staphylococcus lugdunensis | 5.56% | 0% | 0% | 0% |
| Staphylococcus pasteuri | 25% | 0% | 3.85% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 0.7% | 0% |
| Staphylococcus warneri | 0% | 0% | 2.46% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 375