Target protecting FusB-type protein conferring resistance to Fusidic acid [AMR Gene Family]

Accession ARO:3005086
DefinitionFusidic acid resistance determinants through the mediation of target protection. These protein drive the dissociation of EF-G from the ribosome thus counteracting the action of Fusidic acid.
Resistance Mechanismantibiotic target protection
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
4 ontology terms | Show
+ fusB
+ fusC
+ fusD
+ FusF

Chen HJ, et al. 2011. Antimicrob. Agents Chemother. 55(12):5842-9 Identification of fusB-mediated fusidic acid resistance islands in Staphylococcus epidermidis isolates. (PMID 21968364)

Cox G, et al. 2012. Proc. Natl. Acad. Sci. U.S.A. 109(6):2102-7 Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid. (PMID 22308410)

Tomlinson JH, et al. 2016. Sci Rep 6:19524 A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance. (PMID 26781961)