| Accession | ARO:3003735 |
| CARD Short Name | Saur_fusA_FA |
| Definition | The mutations to this gene are involved in altering the translation elongation factor G (EF-G) in association with the ribosome to prevent fusidic acid from binding EF-G and preventing translation. |
| AMR Gene Family | antibiotic resistant fusA |
| Drug Class | fusidane antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Staphylococcus aureusg+wgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + fusidane antibiotic [Drug Class] + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic fusidic acid [Antibiotic] + antibiotic resistant fusA [AMR Gene Family] |
| Publications | Lannergard J, et al. 2009. Antimicrob Agents Chemother 53(5): 2059-2065. Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus. (PMID 19289529) Castanheira M, et al. 2010. Antimicrob. Agents Chemother. 54(9):3614-7 Fusidic acid resistance rates and prevalence of resistance mechanisms among Staphylococcus spp. isolated in North America and Australia, 2007-2008. (PMID 20566766) Castanheira M, et al. 2010. J. Antimicrob. Chemother. 65(7):1353-8 Occurrence and molecular characterization of fusidic acid resistance mechanisms among Staphylococcus spp. from European countries (2008). (PMID 20430787) Nagaev I, et al. 2001. Mol. Microbiol. 40(2):433-9 Biological cost and compensatory evolution in fusidic acid-resistant Staphylococcus aureus. (PMID 11309125) Besier S, et al. 2003. Mol. Microbiol. 47(2):463-9 Molecular analysis of fusidic acid resistance in Staphylococcus aureus. (PMID 12519196) Frosini SM, et al. 2020. Microorganisms 8(12): Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens. (PMID 33353175) |
Prevalence of Staphylococcus aureus fusA with mutation conferring resistance to fusidic acid among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Staphylococcus aureus | 1.92% | 0% | 1.13% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 1350
Legend:
Published Variants:
| PMID: 20566766 | M453I H457Q |
| PMID: 20430787 | D189V,L430S V90A V90I A376V T387I,E449K P404L F441Y L461S A70V,A160V,H457Y |
| PMID: 11309125 | F88L Q115L P404Q V407F D434N T436I G451V G452S G452C G452V G452C,R659L L456F R464C R464H R464S R464L |
| PMID: 12519196 | P406L T436I G452S L456F H457Y H457Y,S416F L461K L461F R464C F652S,Y654N A67T,P406L V90I,H457Q,L461K,A655V |
| PMID: 33353175 | H457N H457L |