cmeB

Accession ARO:3000784
DefinitionCmeB is the inner membrane transporter the CmeABC multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, monobactam, acridine dye, cephalosporin, antibacterial free fatty acids, triclosan, macrolide antibiotic, aminocoumarin antibiotic, penam, glycylcycline, diaminopyrimidine antibiotic, phenicol antibiotic, aminoglycoside antibiotic, fluoroquinolone antibiotic, carbapenem, fusidic acid
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesCampylobacter jejunig
Classification28 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904)

Resistomes

Prevalence of cmeB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Campylobacter coli56%0%48.57%
Campylobacter jejuni99.38%0%92.33%
Vibrio parahaemolyticus0%0%0.08%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 2090


>gb|ABS43151.1|+|cmeB [Campylobacter jejuni subsp. doylei 269.97]
MFSKFFIERPVFASVVAIIISLAGVIGLTNLPIEQYPSLTPPTVKVSATYTGADAQTIASTVASPIEDAINGADNMIYMDSTSSSSGTMS
LTVYFDIGTDPDQATIDVNNRISAATAKMPDAVKKLGVTVRKTSSATLAAISMYSSDGSMSAVDVYNYIALNVLDELKRVPGVGDANAIG
NRNYSLRIWLKPDLLNKFKITATDVISAVNDQNAQYATGKIGEEPVTQKSPYVYSITMQGRLQNPSEFENIILRTNDDGSFLRLKDIADV
EIGSQQYSSQGRLNGNDAVPIIINLQSGANALHTAELVQAKMQELSKNFPKGLTYKIPYDTTKFVIESIKEVIKTFIEALILVIIVMYMF
LKNFRATLIPMIAVPVSLLGTFAGLYVLGFSINLLTLFALILAIGIVVDDAIIVVENIDRILHENEQISVKDAAIQAMQEVSSPVISIVL
VLCAVFIPVSFISGFVGEIQRQFALTLAISVTISGFVALTLTPSLCALFLRRNEGEPFKFVRKFNDFFDWSTSVFSAGVAYILKRTIRFV
LIFCIMLGTIFYLNKAVPNSLVPEEDQGLMIGIINLPSASALHRTISEVDHISQEVLKTNGIKDAMAMIGFDLFTSSLKENAAAMFIGLQ
DWKDRNVSADKIAMELNKKFAFDRNASSIFIGLPPIPGLSITGGFEMYVQNKSGKSYDQIQKDVNKLVAAANQRKELSRVRTTLDTTFPQ
YKLIIDRDKLKHYNLNMQDVFNTMNATIGTYYVNDFSMLGKNFQVNIRAKGDFRNTQDALKNIFVRSNDGKMIPLDSFLTLQRSSGPDDV
KRFNLFPAAQVQGQPAPGYTSGQAIEAIAQVAKETLGDDYSIAWSGSAYQEVSSKGTASYAFALGMIFVFLILAAQYERWLIPLAVVTAV
PFAVFGSFLLVYLRGFSNDIYFQTGLLLLIGLSAKNAILIVEFAMEERFKKGKGVFEAAVAAAKLRFRPIIMTSLAFTFGVLPMIFATGA
GSASRHSLGTGLIGGMIAASTLAIFFVPLFFYLLENFNEWLDKKRGKIHE


>gb|CP000768|+|1406495-1409617|cmeB [Campylobacter jejuni subsp. doylei 269.97]
ATGTTTTCTAAATTTTTTATCGAAAGACCTGTTTTTGCCTCAGTTGTTGCAATTATCATTTCTTTAGCTGGAGTCATAGGTCTTACAAAT
TTACCTATAGAACAATACCCTTCTTTAACCCCTCCTACAGTTAAGGTAAGTGCAACTTACACAGGAGCTGATGCACAAACCATTGCTTCA
ACAGTTGCAAGTCCTATCGAAGATGCAATCAATGGTGCAGATAATATGATTTATATGGATTCGACTTCAAGTTCTTCAGGAACTATGAGT
TTGACCGTTTATTTTGATATTGGCACAGATCCTGATCAAGCCACCATAGATGTTAATAATAGAATTTCAGCTGCAACTGCAAAAATGCCA
GATGCAGTTAAAAAACTTGGAGTAACTGTTAGAAAAACTTCTTCGGCAACCCTAGCTGCAATTTCTATGTATTCAAGTGATGGCTCAATG
AGTGCAGTGGATGTATACAATTACATCGCCTTAAATGTTTTAGATGAGTTAAAAAGGGTTCCAGGAGTTGGAGATGCAAACGCTATAGGA
AATCGTAATTATTCTTTAAGAATTTGGCTAAAACCTGATTTGTTAAATAAATTTAAAATCACAGCTACTGATGTAATTTCTGCGGTTAAC
GATCAAAATGCCCAATACGCAACTGGTAAAATTGGCGAAGAACCTGTAACTCAAAAATCTCCTTATGTTTATTCAATCACCATGCAAGGA
AGATTGCAAAATCCTAGCGAATTTGAAAACATTATTTTAAGAACAAATGATGATGGATCATTTTTAAGACTTAAAGATATAGCTGATGTG
GAAATAGGATCACAACAATACAGCTCACAAGGACGATTAAATGGTAATGATGCGGTTCCGATTATAATCAATCTTCAATCAGGAGCAAAT
GCATTACATACAGCAGAACTTGTCCAGGCTAAAATGCAAGAACTTTCAAAAAATTTCCCAAAAGGTTTAACATATAAAATTCCTTACGAC
ACAACAAAATTTGTGATAGAATCAATCAAAGAAGTAATTAAAACTTTTATTGAAGCTCTAATTTTAGTTATCATTGTTATGTATATGTTC
TTAAAAAATTTCCGCGCAACACTTATTCCTATGATAGCTGTACCTGTTTCATTGTTAGGAACTTTTGCTGGACTTTATGTTTTAGGCTTT
AGTATTAACCTACTTACGCTTTTTGCCTTAATTTTAGCCATAGGGATTGTTGTAGATGATGCGATTATAGTTGTGGAAAATATCGACAGG
ATTTTACACGAGAATGAACAAATAAGCGTAAAAGATGCTGCTATCCAAGCGATGCAAGAAGTTAGCTCTCCAGTCATTTCAATTGTTCTT
GTGCTTTGTGCTGTTTTTATACCGGTTTCTTTTATATCAGGCTTTGTTGGAGAAATTCAAAGACAATTTGCTCTTACCTTAGCTATATCT
GTAACCATATCAGGTTTTGTTGCTCTTACCTTAACACCTTCTTTATGCGCACTCTTTTTGCGACGTAATGAAGGAGAGCCATTTAAATTT
GTAAGGAAATTCAATGATTTTTTTGATTGGAGCACTTCTGTATTTAGCGCAGGAGTAGCATATATTTTAAAAAGAACCATTCGTTTTGTT
TTAATTTTTTGTATCATGCTTGGGACAATTTTTTATCTTAATAAAGCTGTGCCAAATTCTTTAGTTCCTGAAGAAGATCAAGGTTTGATG
ATTGGCATTATTAACCTTCCTTCAGCTTCAGCACTCCATAGAACAATCTCAGAAGTTGATCACATAAGTCAAGAAGTTTTAAAAACTAAT
GGAATTAAAGATGCAATGGCTATGATAGGATTTGATCTTTTTACAAGTTCACTCAAAGAAAACGCTGCTGCAATGTTTATAGGCTTGCAA
GATTGGAAAGATAGAAATGTGAGTGCTGATAAAATCGCCATGGAGCTTAATAAAAAATTTGCCTTTGATCGCAATGCTTCAAGTATATTT
ATAGGCTTACCTCCTATACCTGGATTAAGTATCACAGGTGGTTTTGAAATGTATGTTCAAAACAAAAGTGGAAAAAGCTATGATCAAATT
CAAAAAGATGTAAATAAACTTGTTGCTGCAGCCAACCAAAGAAAAGAACTATCAAGAGTAAGAACAACCCTTGATACAACTTTCCCTCAA
TACAAGCTTATAATTGATAGAGATAAATTAAAACACTACAATCTTAACATGCAAGATGTTTTTAACACGATGAATGCAACTATAGGCACT
TATTATGTTAATGATTTTTCTATGCTAGGTAAAAACTTCCAAGTAAATATCCGCGCAAAAGGTGATTTTAGAAATACACAAGATGCATTA
AAAAATATTTTTGTAAGATCAAATGATGGAAAAATGATACCACTTGATTCTTTCTTAACTTTACAAAGAAGTTCAGGGCCTGATGATGTA
AAACGATTCAACCTTTTCCCAGCAGCACAAGTTCAAGGTCAACCCGCACCAGGTTATACTTCAGGTCAAGCTATAGAAGCGATTGCTCAA
GTAGCAAAAGAAACTTTAGGGGATGATTATTCCATAGCTTGGAGTGGATCAGCTTATCAAGAAGTTTCTAGTAAAGGAACAGCAAGTTAT
GCTTTTGCTTTAGGTATGATATTTGTATTTTTAATTCTAGCTGCTCAATATGAAAGGTGGCTTATACCTTTAGCAGTTGTAACAGCTGTG
CCTTTTGCAGTATTTGGATCATTTTTATTGGTATATTTAAGAGGGTTTAGTAATGATATATATTTTCAAACAGGACTTTTGCTCTTGATT
GGACTTTCAGCTAAAAATGCTATCTTGATCGTAGAATTTGCAATGGAAGAGCGCTTTAAAAAAGGCAAAGGAGTTTTTGAAGCAGCTGTT
GCAGCAGCAAAACTTCGTTTTCGTCCTATCATAATGACTTCTTTGGCGTTTACTTTTGGGGTCTTACCAATGATTTTTGCAACAGGAGCA
GGAAGTGCTTCAAGACACTCTTTAGGAACAGGGCTTATTGGTGGAATGATCGCAGCATCAACTTTAGCGATATTCTTTGTGCCTTTATTT
TTCTATCTTTTAGAAAATTTTAATGAATGGCTAGATAAAAAAAGAGGTAAGATTCATGAATAA