cmeB

Accession ARO:3000784
CARD Short NamecmeB
DefinitionCmeB is the inner membrane transporter the CmeABC multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classfusidane antibiotic, cephalosporin, macrolide antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification16 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904)

Resistomes

Prevalence of cmeB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 2090


>gb|ABS43151.1|+|cmeB [Campylobacter jejuni subsp. doylei 269.97]
MFSKFFIERPVFASVVAIIISLAGVIGLTNLPIEQYPSLTPPTVKVSATYTGADAQTIASTVASPIEDAINGADNMIYMDSTSSSSGTMS
LTVYFDIGTDPDQATIDVNNRISAATAKMPDAVKKLGVTVRKTSSATLAAISMYSSDGSMSAVDVYNYIALNVLDELKRVPGVGDANAIG
NRNYSLRIWLKPDLLNKFKITATDVISAVNDQNAQYATGKIGEEPVTQKSPYVYSITMQGRLQNPSEFENIILRTNDDGSFLRLKDIADV
EIGSQQYSSQGRLNGNDAVPIIINLQSGANALHTAELVQAKMQELSKNFPKGLTYKIPYDTTKFVIESIKEVIKTFIEALILVIIVMYMF
LKNFRATLIPMIAVPVSLLGTFAGLYVLGFSINLLTLFALILAIGIVVDDAIIVVENIDRILHENEQISVKDAAIQAMQEVSSPVISIVL
VLCAVFIPVSFISGFVGEIQRQFALTLAISVTISGFVALTLTPSLCALFLRRNEGEPFKFVRKFNDFFDWSTSVFSAGVAYILKRTIRFV
LIFCIMLGTIFYLNKAVPNSLVPEEDQGLMIGIINLPSASALHRTISEVDHISQEVLKTNGIKDAMAMIGFDLFTSSLKENAAAMFIGLQ
DWKDRNVSADKIAMELNKKFAFDRNASSIFIGLPPIPGLSITGGFEMYVQNKSGKSYDQIQKDVNKLVAAANQRKELSRVRTTLDTTFPQ
YKLIIDRDKLKHYNLNMQDVFNTMNATIGTYYVNDFSMLGKNFQVNIRAKGDFRNTQDALKNIFVRSNDGKMIPLDSFLTLQRSSGPDDV
KRFNLFPAAQVQGQPAPGYTSGQAIEAIAQVAKETLGDDYSIAWSGSAYQEVSSKGTASYAFALGMIFVFLILAAQYERWLIPLAVVTAV
PFAVFGSFLLVYLRGFSNDIYFQTGLLLLIGLSAKNAILIVEFAMEERFKKGKGVFEAAVAAAKLRFRPIIMTSLAFTFGVLPMIFATGA
GSASRHSLGTGLIGGMIAASTLAIFFVPLFFYLLENFNEWLDKKRGKIHE


>gb|CP000768.1|+|1406495-1409617|cmeB [Campylobacter jejuni subsp. doylei 269.97]
ATGTTTTCTAAATTTTTTATCGAAAGACCTGTTTTTGCCTCAGTTGTTGCAATTATCATTTCTTTAGCTGGAGTCATAGGTCTTACAAAT
TTACCTATAGAACAATACCCTTCTTTAACCCCTCCTACAGTTAAGGTAAGTGCAACTTACACAGGAGCTGATGCACAAACCATTGCTTCA
ACAGTTGCAAGTCCTATCGAAGATGCAATCAATGGTGCAGATAATATGATTTATATGGATTCGACTTCAAGTTCTTCAGGAACTATGAGT
TTGACCGTTTATTTTGATATTGGCACAGATCCTGATCAAGCCACCATAGATGTTAATAATAGAATTTCAGCTGCAACTGCAAAAATGCCA
GATGCAGTTAAAAAACTTGGAGTAACTGTTAGAAAAACTTCTTCGGCAACCCTAGCTGCAATTTCTATGTATTCAAGTGATGGCTCAATG
AGTGCAGTGGATGTATACAATTACATCGCCTTAAATGTTTTAGATGAGTTAAAAAGGGTTCCAGGAGTTGGAGATGCAAACGCTATAGGA
AATCGTAATTATTCTTTAAGAATTTGGCTAAAACCTGATTTGTTAAATAAATTTAAAATCACAGCTACTGATGTAATTTCTGCGGTTAAC
GATCAAAATGCCCAATACGCAACTGGTAAAATTGGCGAAGAACCTGTAACTCAAAAATCTCCTTATGTTTATTCAATCACCATGCAAGGA
AGATTGCAAAATCCTAGCGAATTTGAAAACATTATTTTAAGAACAAATGATGATGGATCATTTTTAAGACTTAAAGATATAGCTGATGTG
GAAATAGGATCACAACAATACAGCTCACAAGGACGATTAAATGGTAATGATGCGGTTCCGATTATAATCAATCTTCAATCAGGAGCAAAT
GCATTACATACAGCAGAACTTGTCCAGGCTAAAATGCAAGAACTTTCAAAAAATTTCCCAAAAGGTTTAACATATAAAATTCCTTACGAC
ACAACAAAATTTGTGATAGAATCAATCAAAGAAGTAATTAAAACTTTTATTGAAGCTCTAATTTTAGTTATCATTGTTATGTATATGTTC
TTAAAAAATTTCCGCGCAACACTTATTCCTATGATAGCTGTACCTGTTTCATTGTTAGGAACTTTTGCTGGACTTTATGTTTTAGGCTTT
AGTATTAACCTACTTACGCTTTTTGCCTTAATTTTAGCCATAGGGATTGTTGTAGATGATGCGATTATAGTTGTGGAAAATATCGACAGG
ATTTTACACGAGAATGAACAAATAAGCGTAAAAGATGCTGCTATCCAAGCGATGCAAGAAGTTAGCTCTCCAGTCATTTCAATTGTTCTT
GTGCTTTGTGCTGTTTTTATACCGGTTTCTTTTATATCAGGCTTTGTTGGAGAAATTCAAAGACAATTTGCTCTTACCTTAGCTATATCT
GTAACCATATCAGGTTTTGTTGCTCTTACCTTAACACCTTCTTTATGCGCACTCTTTTTGCGACGTAATGAAGGAGAGCCATTTAAATTT
GTAAGGAAATTCAATGATTTTTTTGATTGGAGCACTTCTGTATTTAGCGCAGGAGTAGCATATATTTTAAAAAGAACCATTCGTTTTGTT
TTAATTTTTTGTATCATGCTTGGGACAATTTTTTATCTTAATAAAGCTGTGCCAAATTCTTTAGTTCCTGAAGAAGATCAAGGTTTGATG
ATTGGCATTATTAACCTTCCTTCAGCTTCAGCACTCCATAGAACAATCTCAGAAGTTGATCACATAAGTCAAGAAGTTTTAAAAACTAAT
GGAATTAAAGATGCAATGGCTATGATAGGATTTGATCTTTTTACAAGTTCACTCAAAGAAAACGCTGCTGCAATGTTTATAGGCTTGCAA
GATTGGAAAGATAGAAATGTGAGTGCTGATAAAATCGCCATGGAGCTTAATAAAAAATTTGCCTTTGATCGCAATGCTTCAAGTATATTT
ATAGGCTTACCTCCTATACCTGGATTAAGTATCACAGGTGGTTTTGAAATGTATGTTCAAAACAAAAGTGGAAAAAGCTATGATCAAATT
CAAAAAGATGTAAATAAACTTGTTGCTGCAGCCAACCAAAGAAAAGAACTATCAAGAGTAAGAACAACCCTTGATACAACTTTCCCTCAA
TACAAGCTTATAATTGATAGAGATAAATTAAAACACTACAATCTTAACATGCAAGATGTTTTTAACACGATGAATGCAACTATAGGCACT
TATTATGTTAATGATTTTTCTATGCTAGGTAAAAACTTCCAAGTAAATATCCGCGCAAAAGGTGATTTTAGAAATACACAAGATGCATTA
AAAAATATTTTTGTAAGATCAAATGATGGAAAAATGATACCACTTGATTCTTTCTTAACTTTACAAAGAAGTTCAGGGCCTGATGATGTA
AAACGATTCAACCTTTTCCCAGCAGCACAAGTTCAAGGTCAACCCGCACCAGGTTATACTTCAGGTCAAGCTATAGAAGCGATTGCTCAA
GTAGCAAAAGAAACTTTAGGGGATGATTATTCCATAGCTTGGAGTGGATCAGCTTATCAAGAAGTTTCTAGTAAAGGAACAGCAAGTTAT
GCTTTTGCTTTAGGTATGATATTTGTATTTTTAATTCTAGCTGCTCAATATGAAAGGTGGCTTATACCTTTAGCAGTTGTAACAGCTGTG
CCTTTTGCAGTATTTGGATCATTTTTATTGGTATATTTAAGAGGGTTTAGTAATGATATATATTTTCAAACAGGACTTTTGCTCTTGATT
GGACTTTCAGCTAAAAATGCTATCTTGATCGTAGAATTTGCAATGGAAGAGCGCTTTAAAAAAGGCAAAGGAGTTTTTGAAGCAGCTGTT
GCAGCAGCAAAACTTCGTTTTCGTCCTATCATAATGACTTCTTTGGCGTTTACTTTTGGGGTCTTACCAATGATTTTTGCAACAGGAGCA
GGAAGTGCTTCAAGACACTCTTTAGGAACAGGGCTTATTGGTGGAATGATCGCAGCATCAACTTTAGCGATATTCTTTGTGCCTTTATTT
TTCTATCTTTTAGAAAATTTTAATGAATGGCTAGATAAAAAAAGAGGTAAGATTCATGAATAA