cmeA

Accession ARO:3000783
DefinitionCmeA is the membrane fusion protein of the CmeABC multidrug efflux complex.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, macrolide antibiotic, phenicol antibiotic, monobactam, fluoroquinolone antibiotic, diaminopyrimidine antibiotic, antibacterial free fatty acids, penam, cephalosporin, glycylcycline, carbapenem, triclosan, aminoglycoside antibiotic, acridine dye, aminocoumarin antibiotic, fusidic acid
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesCampylobacter jejunig
Classification28 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904)

Resistomes

Prevalence of cmeA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Campylobacter coli4%0%2.39%
Campylobacter jejuni99.38%0%96.54%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 710


>gb|ABS43901.1|+|cmeA [Campylobacter jejuni subsp. doylei 269.97]
MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVIIKPQVSGVIVNKLFKAGDKVKRGQTLF
IIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTI
GDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLNLNGETVQGKLYFIDSVIDANSGTVKAKAVF
DNNNSTLLPGAFATITSEGFIQKNGFKVPQIAIKQDQNDVYVLLVKNGKVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSE
VKEIGAQ


>gb|CP000768|+|1405392-1406495|cmeA [Campylobacter jejuni subsp. doylei 269.97]
ATGAAATTATTTCAAAAAAATACTATTTTAGTTTTAGGTGTTGTGTTTTTACTCACTGCTTGCAGCAAAGAAGAAGCGCCAAAAATACAA
ATGCCGCCTCAACCTGTAACAACCATGAGTGCTAAATCTGAAGATTTACCACTTAATTTTACCTATCCTGCCAAACTTGTCAGTGATTAT
GATGTTATTATAAAACCTCAAGTTAGCGGTGTGATAGTAAATAAACTTTTTAAGGCTGGAGATAAGGTAAAAAGAGGACAAACATTATTT
ATTATAGAACAAGCCAAATTTAAAGCTAGCGTTGATTCAGCCTACGGACAAGCGTTAATGGCTAAAGCAACTTTCGAAAATGCAAGTAAA
GATTTTAATCGCTCTGAGGCTCTTTTTAGCAAAAACGCAATCTCTCAAAAAGAATACGACTCTTCTCTTGCTACATTTAATAATGCAAAA
GCTAGTCTAGCAAGTGCTAGAGCACAGCTTGCAAATGCAAGAATTGATCTAGATCATACCGAAATAAAAGCTCCTTTTGATGGTACTATA
GGAGATGCTTTAGTTAATATAGGAGATTATGTAAGCACTTCAACAACTGAACTAGTTAGAGTTACAAATTTAAATCCTATTTACGCAGAT
TTCTTTATTTCAGATACAGATAAACTAAATTTAGTCCGCAATACTCAAAGTGGAAAATGGGATTTAGACAGCATTCATGCAAATTTAAAT
CTTAACGGAGAAACTGTTCAAGGCAAACTTTATTTTATTGATTCTGTTATAGATGCCAATAGTGGAACAGTAAAAGCCAAAGCTGTATTT
GATAACAACAACTCGACACTTTTACCAGGTGCTTTTGCAACGATTACCTCAGAAGGTTTTATACAAAAAAATGGCTTTAAGGTACCTCAA
ATAGCTATTAAACAAGATCAAAATGATGTTTATGTTCTTCTTGTTAAAAATGGAAAAGTAGAAAAATCTTCTGTACATATAAGCTACCAA
AACAATGAATACGCTATTATTGACAAAGGATTGCAAAATGGCGATAAAATCATTTTGGATAATTTTAAAAAAATTCAAGTTGGTAGCGAA
GTTAAAGAAATTGGAGCACAATAA