cmeR

Accession ARO:3000526
CARD Short NamecmeR
DefinitionCmeR is a repressor for the CmeABC multidrug efflux pump, binding to the cmeABC promoter region.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classcephalosporin, fusidane antibiotic, macrolide antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesCampylobacter coliwgs, Campylobacter jejunig+wgs
Resistomes with Sequence VariantsCampylobacter colig+wgs, Campylobacter jejunig+wgs
Classification16 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Lin J, et al. 2005. Antimicrob Agents Chemother 49(3): 1067-1075. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. (PMID 15728904)

Resistomes

Prevalence of cmeR among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Campylobacter coli2.9%0%3.96%0%0%
Campylobacter jejuni97.89%0%97.08%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|CAL34518.1|-|cmeR [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
MNSNRTPSQKVLARQEKIKAVALELFLTKGYQETSLSDIIKLSGGSYSNIYDGFKSKEGLFFEILDDICKKHFHLIYSKTQEIENGTLKE
ILTSFGLAFIEIFNQPEAVAFGKIIYSQVYDKDRHLANWIENNQQNFSYNILMGFFKQQNNSYMKKNAEKLAVLFCTMLKEPYHHLNVLI
NAPLKNKKEQKEHVEFVVNVFLNGINSSKA


>gb|AL111168.1|-|336916-337548|cmeR [Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819]
ATGAACTCAAATAGAACACCATCACAAAAAGTTTTAGCCAGACAAGAAAAAATCAAAGCAGTGGCCTTAGAGCTTTTTTTAACAAAAGGA
TACCAAGAAACAAGTTTGAGTGATATTATTAAATTATCTGGAGGATCTTATTCTAATATTTATGATGGTTTTAAAAGTAAAGAAGGGCTA
TTCTTTGAAATTTTAGATGACATATGTAAAAAACACTTTCATCTTATTTATTCCAAAACACAAGAAATTGAAAATGGCACTTTAAAAGAA
ATTTTAACTTCTTTTGGTTTAGCTTTTATAGAAATTTTCAATCAACCAGAAGCTGTAGCTTTTGGTAAAATTATCTATTCTCAAGTTTAT
GACAAAGATAGACATCTTGCCAATTGGATAGAAAATAATCAACAAAATTTTTCCTATAACATACTTATGGGTTTTTTCAAGCAACAAAAT
AATTCTTATATGAAAAAAAATGCAGAAAAACTTGCTGTTCTTTTTTGCACTATGTTAAAAGAACCTTATCATCATCTTAATGTTTTAATT
AACGCTCCTTTGAAAAATAAAAAAGAACAAAAAGAACATGTTGAATTTGTTGTAAATGTTTTTCTAAATGGAATCAATAGCTCCAAAGCT
TAA

Curator Acknowledgements
Curator Description Most Recent Edit