Accession ARO:3004098
DefinitionLpeAB are components of an efflux pump, which is a macrolide resistance determinant in L. pneumophila Paris strain. Mutations observed in the upstream sequence of lpeAB operon in resistant lineages led to an overexpression of this efflux pump. Sub-inhibitory concentrations of macrolides themselves participated in upregulating this efflux and could constitute a first step in the acquisition of a high macrolide resistance level. As Lpp2879–Lpp2880 is homologous to Escherichia coli AcrAB, lpp2879–lpp2880 was renamed to lpeAB.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ confers_resistance_to_antibiotic spiramycin [Antibiotic]
2 ontology terms | Show
+ LpeA part_of
+ LpeB part_of

Massip C, et al. 2017. J. Antimicrob. Chemother. : Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. (PMID 28137939)