LpeB

Accession ARO:3004100
Synonym(s)lpp2880
CARD Short NameLpeB
DefinitionLpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesLegionella pneumophilag+wgs
Resistomes with Sequence VariantsLegionella pneumophilag+wgs
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Massip C, et al. 2017. J. Antimicrob. Chemother. : Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. (PMID 28137939)

Resistomes

Prevalence of LpeB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Legionella pneumophila15.04%0%11.86%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 1700


>gb|CAH14033.1|+|LpeB [Legionella pneumophila str. Paris]
MKLTSYFIKHPVITIILNAMIVVLGLLCLYNLSVREYPDINFPTITVSASYPNASPDLVETAITNVLEDRLAGIEGLETITSQSSAGYAQ
ITLMFRSGTSMDRALSTTQDAVGVAKALLPPEVRSPTVERQRKSNGLPFIGISLESTSKDFGELTHYANLNLKNVFRSVQGVASVEVWGQ
PYTYNITLQPEKLFSFGVNVDEIVNALAKNRISLPAGNYRNKIPSTLNSELKTREDYENLLIKANSKHPILLKSLANVALETDNSQMRVR
VNGHAGVVLSINKANEANPIEVSKEIRKVIKGLQQGLPKDLKINTIIDQSDFINASIKNIRSAIGEAIFLVLIIVFLFLRNIKATIIPLI
TIPISLLGSLLFLKLFGFSINLMTLLAMVLAIGLVVDDAIIVLENIWRHIESGLSPLDAALKGAREIGFAIIAMTFTLSSVYLPIAFIQG
MLGQLFVEFAVALAGSVFISGIVALTLSPLMCANLLSASSKNWWPQFDNALEKLTKHYSNILQFILKHQKITLLTALISVVACFGFYNLI
SHETAPKEDRGLIGIYIPPVAGEDIGMLDNKTGKLEKKLDAIPEANNRLTFIGDWGGSIVLPLKPHAQRHRSANQIVEKLRPSFNHFPSM
DPHVWSWDTGLPGVDDAGSGSELTLVISTPDHFRQLFDETEKLKSVLDKSKLFAAVNYDLRLDTMGYNIDLDYNQLAKLGLTANQVAKTI
EVFFSGDKSQTFEKDGVVYNISIKGDSSPWTLNELYLTTNEGKSVSLGAITKMQPKAQPATLDHYQQMRSTTLHVQLHKGDSMAKAIEKL
WGTTKEVMPQHYKLTWIGAAKAFHESSNSMLFLFFLSLAFIYAILCTQFENFTDPFIILFTVPLACSGALLFTYLFGQSLNIYTQVGLIT
LIGLISKHGILIVEFANKLHKDGASLPEAIQKSAALRLRPILMTTGAMVFGAIPLVLSHDAGSESRHAIGTVLISGLGLGTLFTLFVLPA
VYNIIKSKLIDMQKTGGKKRCSKE


>gb|CR628336.1|+|3281866-3284910|LpeB [Legionella pneumophila str. Paris]
ATGAAACTCACCAGCTATTTCATCAAACATCCTGTAATCACCATCATCTTAAACGCCATGATTGTTGTTCTGGGGTTATTATGTCTCTAT
AATTTATCCGTTAGGGAATATCCTGATATCAATTTTCCTACAATAACTGTTTCAGCAAGCTACCCCAACGCCAGTCCCGATTTAGTTGAA
ACCGCAATAACCAATGTTCTGGAGGACCGTCTTGCAGGTATAGAAGGGTTAGAAACAATTACGTCGCAATCAAGTGCAGGCTATGCGCAA
ATCACCTTGATGTTTCGTTCCGGAACATCCATGGATAGAGCACTGAGTACCACTCAAGACGCCGTAGGAGTAGCCAAAGCACTTCTGCCA
CCGGAGGTAAGATCGCCAACAGTTGAACGCCAACGCAAATCCAATGGCCTTCCTTTTATTGGGATTTCATTGGAATCAACATCCAAAGAC
TTTGGTGAGCTGACTCATTACGCTAATCTTAATTTAAAAAATGTCTTTCGCAGTGTGCAAGGTGTTGCTTCCGTTGAAGTATGGGGGCAA
CCCTATACATACAACATTACCCTTCAACCTGAAAAATTATTTTCTTTTGGAGTTAATGTTGATGAAATAGTGAATGCGCTCGCAAAAAAT
CGTATTTCGTTGCCCGCAGGTAATTATAGAAATAAAATTCCCAGTACTCTTAATTCTGAGCTGAAAACCCGGGAAGATTATGAGAATCTT
TTAATCAAGGCAAATTCCAAACATCCCATTTTACTCAAATCACTGGCTAATGTCGCATTGGAAACCGATAACTCACAAATGCGAGTTCGC
GTTAATGGGCACGCTGGTGTTGTGCTTTCTATCAATAAAGCGAATGAAGCCAATCCTATTGAAGTCTCTAAAGAAATTAGAAAAGTGATT
AAAGGATTACAACAAGGGTTGCCCAAGGATCTGAAAATAAACACTATTATTGATCAATCGGATTTTATTAATGCCTCCATTAAAAACATT
AGATCCGCGATTGGTGAAGCCATTTTTTTAGTCTTAATCATAGTCTTCCTTTTTTTACGTAATATTAAAGCCACCATCATCCCTCTAATT
ACCATTCCAATTTCATTATTGGGGTCCTTGCTTTTCCTTAAATTGTTTGGTTTTTCAATCAATTTAATGACCTTACTGGCTATGGTATTG
GCAATCGGTTTGGTTGTAGACGATGCGATTATTGTCTTGGAAAACATTTGGCGTCATATTGAAAGCGGATTATCTCCTTTGGATGCTGCG
CTTAAAGGAGCACGTGAAATTGGCTTCGCCATTATAGCGATGACATTTACCCTTAGCAGTGTTTATTTGCCTATAGCCTTTATCCAGGGG
ATGCTGGGACAGCTCTTCGTTGAATTTGCTGTTGCTCTGGCAGGCAGTGTTTTCATTTCGGGGATTGTTGCCCTGACACTTTCACCATTG
ATGTGTGCCAACCTTTTGAGTGCATCTTCTAAAAACTGGTGGCCACAATTCGATAATGCTCTTGAAAAGTTAACTAAACATTACTCCAAT
ATTTTACAATTCATTCTGAAACACCAAAAGATTACTTTGCTAACAGCTCTAATTTCTGTCGTTGCTTGCTTTGGATTTTATAATTTAATT
AGCCATGAAACCGCTCCTAAAGAAGATCGAGGTTTAATAGGTATTTATATCCCTCCTGTAGCAGGAGAAGACATAGGGATGTTGGACAAC
AAAACAGGAAAACTTGAAAAAAAACTAGATGCCATCCCCGAGGCAAATAATCGCCTGACTTTTATTGGTGACTGGGGCGGGTCAATAGTA
CTGCCATTAAAACCTCATGCTCAACGTCATCGAAGTGCGAACCAGATTGTTGAGAAATTAAGACCTTCTTTTAACCACTTCCCCTCCATG
GATCCTCATGTATGGAGTTGGGATACAGGCTTACCAGGAGTTGATGATGCCGGGAGTGGATCTGAATTGACTCTGGTTATTTCTACCCCA
GACCATTTCAGGCAATTATTTGATGAAACTGAAAAATTAAAAAGTGTTCTAGACAAGAGCAAATTATTTGCAGCAGTGAACTATGACCTT
CGCCTTGATACCATGGGATACAATATAGACCTTGATTATAACCAACTGGCGAAACTTGGACTGACAGCAAATCAGGTGGCAAAGACGATT
GAGGTATTTTTCAGTGGCGACAAGTCACAAACCTTTGAAAAAGATGGGGTCGTTTATAATATATCGATTAAAGGAGATTCCTCCCCCTGG
ACTTTGAATGAACTTTATTTAACTACAAATGAAGGGAAGTCTGTTTCATTGGGAGCTATTACCAAAATGCAGCCCAAGGCTCAACCGGCA
ACTCTTGATCATTATCAGCAAATGCGTTCGACCACTCTCCATGTCCAATTACATAAGGGAGACTCTATGGCAAAGGCTATTGAAAAATTA
TGGGGCACTACCAAAGAAGTGATGCCTCAACACTATAAACTGACCTGGATTGGTGCGGCCAAAGCATTCCATGAATCTTCCAATTCCATG
TTATTTTTGTTTTTCTTATCTTTGGCTTTCATCTATGCCATTTTATGCACACAATTCGAGAATTTTACTGACCCCTTCATTATTCTATTC
ACTGTACCACTAGCCTGCTCGGGCGCCTTATTATTCACTTATTTATTTGGACAATCCTTAAACATTTATACTCAGGTAGGTTTGATTACT
TTAATCGGGCTCATTAGCAAACACGGTATTTTAATAGTGGAATTTGCTAATAAACTTCATAAAGATGGTGCTTCGTTGCCAGAAGCTATA
CAGAAATCAGCTGCATTGCGTTTACGGCCTATATTAATGACAACTGGCGCCATGGTTTTTGGCGCCATCCCTTTGGTATTATCGCATGAT
GCGGGTTCTGAATCCCGGCATGCCATAGGAACTGTATTGATTAGCGGGCTCGGTCTTGGAACACTATTTACCCTATTTGTTTTGCCTGCG
GTTTACAACATCATCAAATCCAAACTAATTGATATGCAAAAAACAGGGGGCAAAAAACGGTGCAGCAAAGAATAA