LpeB

Accession ARO:3004100
Synonym(s)lpp2880
DefinitionLpeB is a subunit of the LpeAB efflux pump in Legionella pneumophila, which is homologous to AcrB in E. coli.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, triclosan, diaminopyrimidine antibiotic, acridine dye, monobactam, macrolide antibiotic, glycylcycline, fluoroquinolone antibiotic, phenicol antibiotic, antibacterial free fatty acids, carbapenem, penam, aminoglycoside antibiotic, aminocoumarin antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesLegionella pneumophilag+wgs
Classification26 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Massip C, et al. 2017. J. Antimicrob. Chemother. : Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. (PMID 28137939)

Resistomes

Prevalence of LpeB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Legionella pneumophila16.13%0%14.31%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1700


>gb|CAH14033.1|+|LpeB [Legionella pneumophila str. Paris]
MKLTSYFIKHPVITIILNAMIVVLGLLCLYNLSVREYPDINFPTITVSASYPNASPDLVETAITNVLEDRLAGIEGLETITSQSSAGYAQ
ITLMFRSGTSMDRALSTTQDAVGVAKALLPPEVRSPTVERQRKSNGLPFIGISLESTSKDFGELTHYANLNLKNVFRSVQGVASVEVWGQ
PYTYNITLQPEKLFSFGVNVDEIVNALAKNRISLPAGNYRNKIPSTLNSELKTREDYENLLIKANSKHPILLKSLANVALETDNSQMRVR
VNGHAGVVLSINKANEANPIEVSKEIRKVIKGLQQGLPKDLKINTIIDQSDFINASIKNIRSAIGEAIFLVLIIVFLFLRNIKATIIPLI
TIPISLLGSLLFLKLFGFSINLMTLLAMVLAIGLVVDDAIIVLENIWRHIESGLSPLDAALKGAREIGFAIIAMTFTLSSVYLPIAFIQG
MLGQLFVEFAVALAGSVFISGIVALTLSPLMCANLLSASSKNWWPQFDNALEKLTKHYSNILQFILKHQKITLLTALISVVACFGFYNLI
SHETAPKEDRGLIGIYIPPVAGEDIGMLDNKTGKLEKKLDAIPEANNRLTFIGDWGGSIVLPLKPHAQRHRSANQIVEKLRPSFNHFPSM
DPHVWSWDTGLPGVDDAGSGSELTLVISTPDHFRQLFDETEKLKSVLDKSKLFAAVNYDLRLDTMGYNIDLDYNQLAKLGLTANQVAKTI
EVFFSGDKSQTFEKDGVVYNISIKGDSSPWTLNELYLTTNEGKSVSLGAITKMQPKAQPATLDHYQQMRSTTLHVQLHKGDSMAKAIEKL
WGTTKEVMPQHYKLTWIGAAKAFHESSNSMLFLFFLSLAFIYAILCTQFENFTDPFIILFTVPLACSGALLFTYLFGQSLNIYTQVGLIT
LIGLISKHGILIVEFANKLHKDGASLPEAIQKSAALRLRPILMTTGAMVFGAIPLVLSHDAGSESRHAIGTVLISGLGLGTLFTLFVLPA
VYNIIKSKLIDMQKTGGKKRCSKE


>gb|CR628336.1|+|3281866-3284910|LpeB [Legionella pneumophila str. Paris]
ATGAAACTCACCAGCTATTTCATCAAACATCCTGTAATCACCATCATCTTAAACGCCATGATTGTTGTTCTGGGGTTATTATGTCTCTAT
AATTTATCCGTTAGGGAATATCCTGATATCAATTTTCCTACAATAACTGTTTCAGCAAGCTACCCCAACGCCAGTCCCGATTTAGTTGAA
ACCGCAATAACCAATGTTCTGGAGGACCGTCTTGCAGGTATAGAAGGGTTAGAAACAATTACGTCGCAATCAAGTGCAGGCTATGCGCAA
ATCACCTTGATGTTTCGTTCCGGAACATCCATGGATAGAGCACTGAGTACCACTCAAGACGCCGTAGGAGTAGCCAAAGCACTTCTGCCA
CCGGAGGTAAGATCGCCAACAGTTGAACGCCAACGCAAATCCAATGGCCTTCCTTTTATTGGGATTTCATTGGAATCAACATCCAAAGAC
TTTGGTGAGCTGACTCATTACGCTAATCTTAATTTAAAAAATGTCTTTCGCAGTGTGCAAGGTGTTGCTTCCGTTGAAGTATGGGGGCAA
CCCTATACATACAACATTACCCTTCAACCTGAAAAATTATTTTCTTTTGGAGTTAATGTTGATGAAATAGTGAATGCGCTCGCAAAAAAT
CGTATTTCGTTGCCCGCAGGTAATTATAGAAATAAAATTCCCAGTACTCTTAATTCTGAGCTGAAAACCCGGGAAGATTATGAGAATCTT
TTAATCAAGGCAAATTCCAAACATCCCATTTTACTCAAATCACTGGCTAATGTCGCATTGGAAACCGATAACTCACAAATGCGAGTTCGC
GTTAATGGGCACGCTGGTGTTGTGCTTTCTATCAATAAAGCGAATGAAGCCAATCCTATTGAAGTCTCTAAAGAAATTAGAAAAGTGATT
AAAGGATTACAACAAGGGTTGCCCAAGGATCTGAAAATAAACACTATTATTGATCAATCGGATTTTATTAATGCCTCCATTAAAAACATT
AGATCCGCGATTGGTGAAGCCATTTTTTTAGTCTTAATCATAGTCTTCCTTTTTTTACGTAATATTAAAGCCACCATCATCCCTCTAATT
ACCATTCCAATTTCATTATTGGGGTCCTTGCTTTTCCTTAAATTGTTTGGTTTTTCAATCAATTTAATGACCTTACTGGCTATGGTATTG
GCAATCGGTTTGGTTGTAGACGATGCGATTATTGTCTTGGAAAACATTTGGCGTCATATTGAAAGCGGATTATCTCCTTTGGATGCTGCG
CTTAAAGGAGCACGTGAAATTGGCTTCGCCATTATAGCGATGACATTTACCCTTAGCAGTGTTTATTTGCCTATAGCCTTTATCCAGGGG
ATGCTGGGACAGCTCTTCGTTGAATTTGCTGTTGCTCTGGCAGGCAGTGTTTTCATTTCGGGGATTGTTGCCCTGACACTTTCACCATTG
ATGTGTGCCAACCTTTTGAGTGCATCTTCTAAAAACTGGTGGCCACAATTCGATAATGCTCTTGAAAAGTTAACTAAACATTACTCCAAT
ATTTTACAATTCATTCTGAAACACCAAAAGATTACTTTGCTAACAGCTCTAATTTCTGTCGTTGCTTGCTTTGGATTTTATAATTTAATT
AGCCATGAAACCGCTCCTAAAGAAGATCGAGGTTTAATAGGTATTTATATCCCTCCTGTAGCAGGAGAAGACATAGGGATGTTGGACAAC
AAAACAGGAAAACTTGAAAAAAAACTAGATGCCATCCCCGAGGCAAATAATCGCCTGACTTTTATTGGTGACTGGGGCGGGTCAATAGTA
CTGCCATTAAAACCTCATGCTCAACGTCATCGAAGTGCGAACCAGATTGTTGAGAAATTAAGACCTTCTTTTAACCACTTCCCCTCCATG
GATCCTCATGTATGGAGTTGGGATACAGGCTTACCAGGAGTTGATGATGCCGGGAGTGGATCTGAATTGACTCTGGTTATTTCTACCCCA
GACCATTTCAGGCAATTATTTGATGAAACTGAAAAATTAAAAAGTGTTCTAGACAAGAGCAAATTATTTGCAGCAGTGAACTATGACCTT
CGCCTTGATACCATGGGATACAATATAGACCTTGATTATAACCAACTGGCGAAACTTGGACTGACAGCAAATCAGGTGGCAAAGACGATT
GAGGTATTTTTCAGTGGCGACAAGTCACAAACCTTTGAAAAAGATGGGGTCGTTTATAATATATCGATTAAAGGAGATTCCTCCCCCTGG
ACTTTGAATGAACTTTATTTAACTACAAATGAAGGGAAGTCTGTTTCATTGGGAGCTATTACCAAAATGCAGCCCAAGGCTCAACCGGCA
ACTCTTGATCATTATCAGCAAATGCGTTCGACCACTCTCCATGTCCAATTACATAAGGGAGACTCTATGGCAAAGGCTATTGAAAAATTA
TGGGGCACTACCAAAGAAGTGATGCCTCAACACTATAAACTGACCTGGATTGGTGCGGCCAAAGCATTCCATGAATCTTCCAATTCCATG
TTATTTTTGTTTTTCTTATCTTTGGCTTTCATCTATGCCATTTTATGCACACAATTCGAGAATTTTACTGACCCCTTCATTATTCTATTC
ACTGTACCACTAGCCTGCTCGGGCGCCTTATTATTCACTTATTTATTTGGACAATCCTTAAACATTTATACTCAGGTAGGTTTGATTACT
TTAATCGGGCTCATTAGCAAACACGGTATTTTAATAGTGGAATTTGCTAATAAACTTCATAAAGATGGTGCTTCGTTGCCAGAAGCTATA
CAGAAATCAGCTGCATTGCGTTTACGGCCTATATTAATGACAACTGGCGCCATGGTTTTTGGCGCCATCCCTTTGGTATTATCGCATGAT
GCGGGTTCTGAATCCCGGCATGCCATAGGAACTGTATTGATTAGCGGGCTCGGTCTTGGAACACTATTTACCCTATTTGTTTTGCCTGCG
GTTTACAACATCATCAAATCCAAACTAATTGATATGCAAAAAACAGGGGGCAAAAAACGGTGCAGCAAAGAATAA