spiramycin [Antibiotic]

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Accession ARO:3000156
Synonym(s)rovamycin
DefinitionSpiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis.
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
Sub-Term(s)
27 ontology terms | Show
+ 50S ribosomal subunit P-site targeted_by_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmC' confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmI confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
+ LpeAB confers_resistance_to_antibiotic
Publications

Mazzei T, et al. 1993. J Antimicrob Chemother 31(SUPPL C): 1-9. Chemistry and mode of action of macrolides. (PMID 7683018)