| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000156 |
| Synonym(s) | rovamycin |
| Definition | Spiramycin is a 16-membered macrolide and is natural product produced by Streptomyces ambofaciens. It binds to the 50S subunit of bacterial ribosomes and inhibits peptidyl transfer activity to disrupt protein synthesis. |
| SMILES | CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@H]2CC[C@H](N(C)C)[C@@H](C)O2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1O |
| PubChem | 6419898 |
| ChEMBL | CHEMBL453514 |
| ChEBI | 85260 |
| CAS | 24916-50-5 |
| Drug Class | macrolide antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + macrolide antibiotic [Drug Class] |
| Sub-Term(s) | 33 ontology terms | Show + 50S ribosomal subunit P-site targeted_by_antibiotic + ErmC confers_resistance_to_antibiotic + ErmE confers_resistance_to_antibiotic + ErmA confers_resistance_to_antibiotic + ErmB confers_resistance_to_antibiotic + Erm(37) confers_resistance_to_antibiotic + ErmD confers_resistance_to_antibiotic + ErmF confers_resistance_to_antibiotic + ErmG confers_resistance_to_antibiotic + ErmN confers_resistance_to_antibiotic + ErmQ confers_resistance_to_antibiotic + ErmR confers_resistance_to_antibiotic + ErmT confers_resistance_to_antibiotic + ErmX confers_resistance_to_antibiotic + Erm(33) confers_resistance_to_antibiotic + Erm(34) confers_resistance_to_antibiotic + Erm(38) confers_resistance_to_antibiotic + Erm(39) confers_resistance_to_antibiotic + Erm(41) confers_resistance_to_antibiotic + Erm(35) confers_resistance_to_antibiotic + Erm(36) confers_resistance_to_antibiotic + mphB confers_resistance_to_antibiotic + mphC confers_resistance_to_antibiotic + LpeAB confers_resistance_to_antibiotic + srmB confers_resistance_to_antibiotic + Erm(47) confers_resistance_to_antibiotic + ErmO-srmA confers_resistance_to_antibiotic + Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic + Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic + Streptomyces ambofaciens 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic + erm(40) confers_resistance_to_antibiotic + ermZ confers_resistance_to_antibiotic + mreA confers_resistance_to_antibiotic |
| Publications | Mazzei T, et al. 1993. J Antimicrob Chemother 31(SUPPL C): 1-9. Chemistry and mode of action of macrolides. (PMID 7683018) |
| Curator | Description | Most Recent Edit |
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