50S ribosomal subunit P-site

Accession ARO:3000757
DefinitionThe P-site of the ribosome binds the peptidyl-tRNA with the growing polypeptide chain, and is a common target for many antibiotics that inhibit the 50S ribosomal subunit. Some antibiotics (oxazolidinones) block the 50S subunit from interacting with the 30S subunit to prevent the formation of the ribosomal complex. Other antibiotics (thiostrepton) block the 50S subunit from interacting with elongation factors G and Tu (EF-G, Ef-Tu), preventing GTP-dependent reactions of peptidyl transferase, and translocation, respectively. Other antibiotics (macrolides) prevent protein translocation.
Drug Classoxazolidinone antibiotic
Classification3 ontology terms | Show
Parent Term(s)13 ontology terms | Show
+ targeted_by oxazolidinone antibiotic [Drug Class]
+ targeted_by_antibiotic thiostrepton [Antibiotic]
+ 50S ribosomal subunit
+ targeted_by_antibiotic linezolid [Antibiotic]
+ targeted_by_antibiotic erythromycin [Antibiotic]
+ targeted_by_antibiotic azithromycin [Antibiotic]
+ targeted_by_antibiotic clarithromycin [Antibiotic]
+ targeted_by_antibiotic dirithromycin [Antibiotic]
+ targeted_by_antibiotic roxithromycin [Antibiotic]
+ targeted_by_antibiotic spiramycin [Antibiotic]
+ targeted_by_antibiotic telithromycin [Antibiotic]
+ targeted_by_antibiotic tylosin [Antibiotic]
+ targeted_by streptogramin B antibiotic
Publications

Naaktgeboren N, et al. 1976. Eur J Biochem 70(1): 39-47. The mode of action of thiostrepton in the initiation of protein synthesis. (PMID 795651)

Laursen BS, et al. 2005. Microbiol Mol Biol Rev 69(1): 101-123. Initiation of protein synthesis in bacteria. (PMID 15755955)

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)