clarithromycin [Antibiotic]

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Accession ARO:0000065
Synonym(s)CLR Klaricid Naxy Biaxin Macladin Veclam Klacid Clathromycin Clarith Clambiotic
DefinitionClarithromycin is a methyl derivative of erythromycin, sharing the 14-carbon macrolide ring. The antibiotic binds to the 50S subunit of the ribosome and is used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), and skin structure infections.
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
Sub-Term(s)
37 ontology terms | Show
+ EreA confers_resistance_to_antibiotic
+ EreB confers_resistance_to_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmC' confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmI confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ mphA confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
+ Helicobacter pylori 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Escherichia coli 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Mycobacteroides abscessus 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Mycobacteroides chelonae 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Mycobacterium avium 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Mycobacterium kansasii 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis 23S rRNA with mutation conferring resistance to clarithromycin confers_resistance_to_antibiotic
+ 50S ribosomal subunit P-site targeted_by_antibiotic
Publications

Mazzei T, et al. 1993. J Antimicrob Chemother 31(SUPPL C): 1-9. Chemistry and mode of action of macrolides. (PMID 7683018)