erm(46)

Accession ARO:3004596
Synonym(s)ErmREQ
CARD Short Nameerm(46)
Definitionerm(46) is transferable determinant that confers resistance to macrolides.
AMR Gene FamilyErm 23S ribosomal RNA methyltransferase
Drug Classmacrolide antibiotic, lincosamide antibiotic, streptogramin antibiotic
Resistance Mechanismantibiotic target alteration
Classification12 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic clarithromycin [Antibiotic]
+ confers_resistance_to_antibiotic azithromycin [Antibiotic]
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family]
Publications

Anastasi E, et al. 2015. J Antimicrob Chemother 70(12):3184-90 Novel transferable erm(46) determinant responsible for emerging macrolide resistance in Rhodococcus equi. (PMID 26377866)

Resistomes

Prevalence of erm(46) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|AJF36617.1|+|erm(46) [Rhodococcus hoagii]
MPTYRSGRHELGQNFLTDRKAVDTIVDLVSRTDGPIIEIGSGGGALTLPLQALRRPITAIEIDPRHVQKLQHRVDPSTTVVHGDFLRYRL
PRTPHTIVGNLPFHHTTAMLRRILHAEHWTASVLLVQWEVARRRAAVGGATMMTAQWWPWYDFGLAGRVSASAFTPRPGVDAGLMTIARR
TVPLVDPALRPRYSTFVHTVFTSKGHGLHQILPRVAGDPEKAAVKKWLAGQRFRGTPLPRDLSPGQWSELFAIIDRRSPATDRKRAEYRR


>gb|KM679362.1|+|1-813|erm(46) [Rhodococcus hoagii]
ATGCCTACCTACCGTTCCGGCCGTCACGAGCTCGGCCAGAACTTCCTCACGGACCGCAAAGCAGTCGATACGATCGTCGACCTCGTTTCT
CGAACAGACGGCCCGATCATCGAAATCGGCTCCGGCGGTGGGGCGTTGACATTGCCCCTGCAGGCGCTGCGTCGACCGATCACAGCTATC
GAGATCGATCCGCGACATGTGCAAAAGCTCCAACATCGCGTCGATCCGAGTACGACGGTCGTGCACGGCGACTTCCTGCGCTACCGACTG
CCCCGAACACCGCACACCATCGTGGGGAACTTGCCGTTCCACCACACCACGGCGATGTTGCGGCGAATCCTCCACGCCGAACACTGGACA
GCGTCGGTCCTGCTCGTGCAGTGGGAGGTTGCACGTCGTCGTGCGGCGGTCGGTGGCGCAACGATGATGACTGCGCAATGGTGGCCGTGG
TACGACTTCGGCCTGGCCGGCCGTGTTTCCGCATCGGCGTTCACACCACGGCCGGGAGTCGATGCAGGGCTGATGACCATCGCTCGGCGG
ACCGTTCCACTCGTCGACCCCGCGCTACGTCCCCGATACAGCACCTTCGTCCACACCGTCTTCACCAGCAAGGGCCACGGCCTGCATCAG
ATCTTGCCGCGGGTGGCTGGCGATCCTGAGAAGGCCGCGGTTAAGAAGTGGCTCGCTGGCCAGCGATTTCGAGGCACACCGCTGCCGCGC
GACCTCTCACCCGGACAATGGTCCGAGCTCTTCGCGATCATCGATCGACGCTCTCCGGCTACCGATCGGAAGCGGGCTGAGTACCGGCGA
TGA