23S ribosomal RNA methyltransferase

Accession ARO:3004274
DefinitionMethyltransferases that modify the 23S rRNA of the 50S subunit of bacterial ribosomes, conferring resistance to drugs that target 23S rRNA.
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)1 ontology terms | Show
5 ontology terms | Show

Morales G, et al. 2010. Clin Infect Dis 50(6): 821-825. Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. (PMID 20144045)

Park AK, et al. 2010. FEMS Microbiol Lett 309(2): 151-162. Phylogenetic analysis of rRNA methyltransferases, Erm and KsgA, as related to antibiotic resistance. (PMID 20618865)

Smith TM, et al. 1995. Gene 164(1): 137-142. The thiostrepton-resistance-encoding gene in Streptomyces laurentii is located within a cluster of ribosomal protein operons. (PMID 7590303)