Erm 23S ribosomal RNA methyltransferase [AMR Gene Family]

Accession ARO:3000560
DefinitionErm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype.
Drug Classlincosamide antibiotic, macrolide antibiotic, streptogramin antibiotic
Resistance Mechanismantibiotic target alteration
Classification11 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class streptogramin antibiotic [Drug Class]
+ determinant of streptogramin resistance
+ determinant of lincosamide resistance
+ determinant of macrolide resistance
+ 23S ribosomal RNA methyltransferase
44 ontology terms | Show

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)

Park AK, et al. 2010. FEMS Microbiol Lett 309(2): 151-162. Phylogenetic analysis of rRNA methyltransferases, Erm and KsgA, as related to antibiotic resistance. (PMID 20618865)