| Accession | ARO:3000560 |
| Definition | Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype. |
| Drug Class | macrolide antibiotic, lincosamide antibiotic, streptogramin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic target modifying enzyme + ribosomal alteration conferring antibiotic resistance + rRNA methyltransferase conferring antibiotic resistance + antibiotic molecule |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_drug_class lincosamide antibiotic [Drug Class] + confers_resistance_to_drug_class streptogramin antibiotic [Drug Class] + 23S ribosomal RNA methyltransferase |
| Sub-Term(s) | 47 ontology terms | Show + ErmB + ErmA + ErmE + ErmC + ErmG + ErmF + ErmD + Erm(37) + ErmN + ErmQ + ErmR + ErmT + ErmX + Erm(31) + Erm(33) + Erm(34) + Erm(38) + Erm(39) + Erm(41) + Erm(35) + Erm(36) + Erm(49) + Erm(K) + Erm(30) + ErmO-srmA + ErmS + ErmU + ErmW + ErmH + ErmV + ErmY + Erm(42) + Erm(43) + Erm(48) + erm(32) + erm(45) + erm(46) + Erm(47) + Erm(44)v + ermZ + Erm(O)-lrm + erm(40) + 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) + Erm(50) + Erm(52) + Erm(51) + erm(56) |
| Publications | Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867) Park AK, et al. 2010. FEMS Microbiol Lett 309(2): 151-162. Phylogenetic analysis of rRNA methyltransferases, Erm and KsgA, as related to antibiotic resistance. (PMID 20618865) |