Erm(48)

Accession ARO:3004094
CARD Short NameErm(48)
DefinitionErm(48) is a macrolide-lincosamide-streptogramin resistance gene identified on resistance plasmid pJW2311.
AMR Gene FamilyErm 23S ribosomal RNA methyltransferase
Drug Classstreptogramin antibiotic, streptogramin B antibiotic, lincosamide antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesStaphylococcus equorumwgs
Resistomes with Sequence VariantsStaphylococcus equorumwgs
Classification13 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_antibiotic clindamycin [Antibiotic]
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family]
+ confers_resistance_to_antibiotic pristinamycin IA [Antibiotic]
Publications

Wipf JRK, et al. 2017. Antimicrob. Agents Chemother. : New macrolide-lincosamide-streptogramin B resistance gene erm(48) on the novel plasmid pJW2311 in Staphylococcus xylosus. (PMID 28438941)

Resistomes

Prevalence of Erm(48) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Staphylococcus equorum0%0%1.79%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|CZT31773.1|+|Erm(48) [Staphylococcus xylosus]
MNNKNPKDSQNFITSQKYINEILQNTNIESNDNIIEIGTGKGHFTKALLKISHFVTGIEIDRNLYYKLKKDTDLYDNLKLINKDVLRFQF
HQNEPYKIFGSIPYNISTEIIKKILYESKSEFNYLIVELGFAKRLLNKKRALSLLLLPKMDVEILKIIPNVYFHPKPTVDSALILLKRHK
PLVSEKDEKIYHFFVYRWVNKEYKKLFTKNQFNKTLNHANVQDINELSKEQFISIFNSYKLFN


>gb|LT223129.1|+|47370-48101|Erm(48) [Staphylococcus xylosus]
ATGAATAACAAAAACCCAAAAGATTCACAAAATTTTATAACATCTCAAAAATATATAAATGAAATCTTACAAAATACTAATATAGAATCA
AATGACAATATCATTGAAATAGGAACAGGCAAGGGGCATTTTACAAAAGCATTATTAAAAATATCTCACTTTGTAACTGGAATAGAAATT
GATAGGAATTTGTATTATAAATTAAAAAAAGACACTGACCTATATGATAATCTTAAATTAATCAATAAAGATGTATTGAGATTCCAATTT
CATCAAAATGAACCTTATAAGATTTTTGGGAGTATTCCCTATAATATTAGTACAGAAATAATTAAAAAGATTTTGTATGAAAGTAAGTCA
GAATTTAACTATCTAATTGTGGAGCTAGGATTTGCTAAACGTCTCTTAAATAAAAAAAGAGCGCTAAGTTTATTATTATTACCTAAAATG
GATGTTGAAATTTTAAAAATAATCCCTAACGTTTATTTCCATCCTAAACCAACAGTAGATTCGGCACTAATTTTATTAAAACGACATAAG
CCTTTAGTTTCAGAGAAAGATGAAAAGATATATCATTTTTTTGTATATAGATGGGTGAACAAAGAATATAAGAAACTGTTTACCAAAAAT
CAATTTAATAAAACATTGAATCATGCAAATGTGCAAGACATCAATGAATTATCAAAAGAACAATTTATATCTATTTTTAATAGTTATAAA
TTGTTTAATTGA