| Accession | ARO:0000050 |
| Definition | Streptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics. |
| Drug Class | streptogramin antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + streptogramin antibiotic [Drug Class] |
| Sub-Term(s) | 10 ontology terms | Show + pristinamycin IA [Antibiotic] + quinupristin [Antibiotic] + pristinamycin IB [Antibiotic] + virginiamycin S2 [Antibiotic] + pristinamycin IC [Antibiotic] + vernamycin C [Antibiotic] + patricin A [Antibiotic] + patricin B [Antibiotic] + ostreogrycin B3 [Antibiotic] + 50S ribosomal subunit P-site targeted_by |
| Publications | Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867) Leclercq R and Courvalin P. 1998. Lancet 352(9128): 591-592. Streptogramins: an answer to antibiotic resistance in gram-positive bacteria. (PMID 9746015) Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955) |