streptogramin B antibiotic [Drug Class]

Accession ARO:0000050
DefinitionStreptogramin B antibiotics are are cyclic hepta- or hexa-depsipeptides. Type B streptogramins block the peptide exit tunnel of the 50S bacterial ribosome. The general composition of group B streptogramins is 3-hydroxypicolinic acid-L-Thr-D-aminobutyric acid (or D-Ala)-L-Pro-L-Phe (or 4-N-,N-(dimethylamino)-L-Phe)-X-L-phenylglycine. Used alone, streptogramin B antibiotics are bacteriostatic, but is bactericidal when used with streptogramin A antibiotics.
Drug Classstreptogramin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
10 ontology terms | Show
+ pristinamycin IA [Antibiotic]
+ quinupristin [Antibiotic]
+ pristinamycin IB [Antibiotic]
+ virginiamycin S2 [Antibiotic]
+ pristinamycin IC [Antibiotic]
+ vernamycin C [Antibiotic]
+ patricin A [Antibiotic]
+ patricin B [Antibiotic]
+ ostreogrycin B3 [Antibiotic]
+ 50S ribosomal subunit P-site targeted_by

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)

Leclercq R and Courvalin P. 1998. Lancet 352(9128): 591-592. Streptogramins: an answer to antibiotic resistance in gram-positive bacteria. (PMID 9746015)

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)