Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3000584 |
Definition | Quinupristin is a type B streptogramin and a semisynthetic derivative of pristinamycin 1A. It is a component of the drug Synercid and interacts with the 50S subunit of the bacterial ribosome to inhibit protein synthesis. |
SMILES | CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2CC(=O)[C@H](CS[C@@H]3CN4CCC3CC4)CN2C(=O)[C@H](Cc2ccc(N(C)C)cc2)N(C)C(=O)[C@@H]2CCCN2C1=O |
PubChem | 5388937 |
ChEMBL | CHEMBL1200649 |
ChEBI | 8732 |
Drug Class | streptogramin antibiotic, streptogramin B antibiotic |
Classification | 3 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + streptogramin B antibiotic [Drug Class] |
Sub-Term(s) | 30 ontology terms | Show + antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by_antibiotic + lsaA confers_resistance_to_antibiotic + msrA confers_resistance_to_antibiotic + ErmC confers_resistance_to_antibiotic + ErmE confers_resistance_to_antibiotic + ErmA confers_resistance_to_antibiotic + ErmB confers_resistance_to_antibiotic + Erm(37) confers_resistance_to_antibiotic + ErmD confers_resistance_to_antibiotic + ErmF confers_resistance_to_antibiotic + ErmG confers_resistance_to_antibiotic + ErmN confers_resistance_to_antibiotic + ErmQ confers_resistance_to_antibiotic + ErmR confers_resistance_to_antibiotic + ErmT confers_resistance_to_antibiotic + ErmX confers_resistance_to_antibiotic + Erm(33) confers_resistance_to_antibiotic + Erm(34) confers_resistance_to_antibiotic + Erm(38) confers_resistance_to_antibiotic + Erm(39) confers_resistance_to_antibiotic + Erm(41) confers_resistance_to_antibiotic + Erm(35) confers_resistance_to_antibiotic + Erm(36) confers_resistance_to_antibiotic + vgbA confers_resistance_to_antibiotic + vgbB confers_resistance_to_antibiotic + vgbC confers_resistance_to_antibiotic + msrB confers_resistance_to_antibiotic + msrC confers_resistance_to_antibiotic + Erm(47) confers_resistance_to_antibiotic + quinupristin-dalfopristin [Antibiotic] has_part |
Publications | Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955) Leclercq R and Courvalin P. 1998. Lancet 352(9128): 591-592. Streptogramins: an answer to antibiotic resistance in gram-positive bacteria. (PMID 9746015) |
Curator | Description | Most Recent Edit |
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