| Accession | ARO:3001307 |
| Synonym(s) | vgh |
| CARD Short Name | vgbA |
| Definition | vgbA inactivates streptogramin B-type antibiotics by linearizing the lactone ring on the ester bond using an elimination mechanism, thus conferring resistance to these compounds. |
| AMR Gene Family | streptogramin vgb lyase |
| Drug Class | streptogramin antibiotic, streptogramin B antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Enterococcus faecaliswgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + streptogramin antibiotic [Drug Class] + antibiotic inactivation enzyme + streptogramin B antibiotic [Drug Class] + linearization of antibiotic conferring resistance + streptogramin inactivation enzyme |
| Parent Term(s) | 10 ontology terms | Show + streptogramin vgb lyase [AMR Gene Family] + confers_resistance_to_antibiotic ostreogrycin B3 [Antibiotic] + confers_resistance_to_antibiotic patricin A [Antibiotic] + confers_resistance_to_antibiotic patricin B [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IA [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IB [Antibiotic] + confers_resistance_to_antibiotic quinupristin [Antibiotic] + confers_resistance_to_antibiotic virginiamycin S2 [Antibiotic] + confers_resistance_to_antibiotic pristinamycin IC [Antibiotic] + confers_resistance_to_antibiotic vernamycin C [Antibiotic] |
| Publications | Mukhtar TA, et al. 2005. Chem Biol 12(2): 229-235. Chimeric streptogramin-tyrocidine antibiotics that overcome streptogramin resistance. (PMID 15734650) Korczynska M, et al. 2007. Proc Natl Acad Sci U S A 104(25): 10388-10393. Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase. (PMID 17563376) Mukhtar TA, et al. 2001. Biochemistry 40(30): 8877-8886. Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. (PMID 11467949) |
Prevalence of vgbA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Enterococcus faecalis | 0% | 0% | 0.04% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 550
