streptogramin vgb lyase [AMR Gene Family]

Accession ARO:3000376
Definitionvgb (Virginiamycin B) lyase inactivates type B streptogramin antibiotics by linearizing the streptogramin lactone ring at the ester linkage through an elimination mechanism, thus conferring resistance to these compounds.
Drug Classstreptogramin antibiotic
Resistance Mechanismantibiotic inactivation
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
3 ontology terms | Show
+ vgbA
+ vgbB
+ vgbC

Mukhtar TA, et al. 2001. Biochemistry 40(30): 8877-8886. Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. (PMID 11467949)