| Accession | ARO:3000233 |
| Definition | Resistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance. |
| Resistance Mechanism | antibiotic inactivation |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Kehoe LE, et al. 2003. J Biol Chem 278(32): 29963-29970. Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens. (PMID 12771141) Mukhtar TA, et al. 2001. Biochemistry 40(30): 8877-8886. Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. (PMID 11467949) |