streptogramin inactivation enzyme

Accession ARO:3000233
DefinitionResistance to streptogramin antibiotics may be conferred through enzymatic inactivation. There are two known mechanisms of streptogramin inactivation shown clinically to confer resistance: 1) vgB lyase enzymes linearize type B streptogramin antibiotics by breaking the ester linkage; 2) vat acetyltransferase enzymes modify type A streptogramin antibiotics by transferring an acetyl group from acetyl-CoA to the secondary streptogramin hydroxyl. Both mechanisms result in antibiotic inactivation thus conferring resistance.
Drug Classstreptogramin antibiotic
Classification4 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
+ streptogramin vgb lyase [AMR Gene Family]
+ streptogramin vat acetyltransferase [AMR Gene Family]
Publications

Kehoe LE, et al. 2003. J Biol Chem 278(32): 29963-29970. Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens. (PMID 12771141)

Mukhtar TA, et al. 2001. Biochemistry 40(30): 8877-8886. Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis. (PMID 11467949)