streptogramin vat acetyltransferase [AMR Gene Family]

Accession ARO:3000453
Synonym(s)Streptogramin A acetyltransferase (SAT)
Definitionvat (Virginiamycin acetyltransferases) enzymes catalyze the transfer of an acetyl group from acetyl-CoA to the secondary alcohol of streptogramin A compounds, thus inactivating virginiamycin-like antibiotics and conferring resistance to these compounds.
Drug Classstreptogramin antibiotic, streptogramin A antibiotic
Resistance Mechanismantibiotic inactivation
Classification8 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ streptogramin inactivation enzyme
+ confers_resistance_to_antibiotic dalfopristin [Antibiotic]
+ confers_resistance_to_antibiotic griseoviridin [Antibiotic]
+ confers_resistance_to_antibiotic madumycin II [Antibiotic]
+ confers_resistance_to_antibiotic virginiamycin M1 [Antibiotic]
+ participates_in acylation of antibiotic conferring resistance
+ confers_resistance_to_drug_class streptogramin antibiotic [Drug Class]
8 ontology terms | Show
+ vatA
+ vatB
+ vatC
+ vatD
+ vatE
+ vatH
+ vatF
+ VatI

Kehoe LE, et al. 2003. J Biol Chem 278(32): 29963-29970. Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens. (PMID 12771141)

Jung YH, et al. 2010. Antimicrob Agents Chemother 54(11): 4744-4749. Characterization of two newly identified genes, vgaD and vatG, conferring resistance to streptogramin A in Enterococcus faecium. (PMID 20713681)

Sugantino M and Roderick SL. 2002. Biochemistry 41(7): 2209-2216. Crystal structure of Vat(D): an acetyltransferase that inactivates streptogramin group A antibiotics. (PMID 11841212)