streptogramin antibiotic [Drug Class]

Accession ARO:0000026
DefinitionStreptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
20 ontology terms | Show
+ streptogramin A antibiotic
+ streptogramin B antibiotic
+ determinant of streptogramin resistance confers_resistance_to_drug_class
+ lmrP confers_resistance_to_drug_class
+ msrB confers_resistance_to_drug_class
+ msrC confers_resistance_to_drug_class
+ mel confers_resistance_to_drug_class
+ msrE confers_resistance_to_drug_class
+ lsaB confers_resistance_to_drug_class
+ lsaC confers_resistance_to_drug_class
+ salA confers_resistance_to_drug_class
+ eatAv confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to streptogramins antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ streptogramin vat acetyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ streptogramin vgb lyase [AMR Gene Family] confers_resistance_to_drug_class
+ Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ ABC-F ATP-binding cassette ribosomal protection protein [AMR Gene Family] confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ msr-type ABC-F protein confers_resistance_to_drug_class
+ antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by
Publications

Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955)