| Accession | ARO:0000026 |
| Definition | Streptogramin antibiotics are natural products produced by various members of the Streptomyces genus. These antibiotics bind to the P site of the 50S subunit of bacterial ribosomes to inhibit protein synthesis. The family consists of two subgroups, type A and type B, which are simultaneously produced by the same bacterial species in a ratio of roughly 70:30. |
| Classification | 1 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 12 ontology terms | Show + streptogramin A antibiotic [Drug Class] + streptogramin B antibiotic [Drug Class] + antibiotic sensitive peptidyl transferase (23S rRNA) targeted_by + lmrP confers_resistance_to_drug_class + 23S rRNA with mutation conferring resistance to streptogramins antibiotics [AMR Gene Family] confers_resistance_to_drug_class + streptogramin vat acetyltransferase [AMR Gene Family] confers_resistance_to_drug_class + streptogramin vgb lyase [AMR Gene Family] confers_resistance_to_drug_class + Erm 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class + 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class + Cfr 23S ribosomal RNA methyltransferase [AMR Gene Family] confers_resistance_to_drug_class + lsa-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class + msr-type ABC-F protein [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | Mukhtar TA and Wright GD. 2005. Chem Rev 105(2): 529-542. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. (PMID 15700955) |