| Accession | ARO:3004057 |
| Definition | Point mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics. |
| Drug Class | oxazolidinone antibiotic, macrolide antibiotic, lincosamide antibiotic, streptogramin antibiotic, glycopeptide antibiotic, phenicol antibiotic, pleuromutilin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistant gene variant or mutant + rRNA with mutation conferring antibiotic resistance + oxazolidinone antibiotic [Drug Class] |
| Parent Term(s) | 9 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_drug_class lincosamide antibiotic [Drug Class] + confers_resistance_to_drug_class streptogramin antibiotic [Drug Class] + confers_resistance_to_antibiotic linezolid [Antibiotic] + confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class] + confers_resistance_to_drug_class glycopeptide antibiotic [Drug Class] + 23S rRNA with mutation conferring antibiotic resistance + confers_resistance_to_drug_class phenicol antibiotic [Drug Class] + confers_resistance_to_drug_class pleuromutilin antibiotic [Drug Class] |
| Sub-Term(s) | 1 ontology terms | Show |
| Publications | Musumeci R, et al. 2016. New Microbiol. 39(4):269-273 Resistance to linezolid in Staphylococcus spp. clinical isolates associated with ribosomal binding site modifications: novel mutation in domain V of 23S rRNA. (PMID 27727405) |