23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family]

Accession ARO:3004057
DefinitionPoint mutations in the 23S rRNA subunit may confer resistance to linezolid and other oxazolidinone antibiotics.
Drug Classoxazolidinone antibiotic, glycopeptide antibiotic, streptogramin antibiotic, macrolide antibiotic, phenicol antibiotic, lincosamide antibiotic, pleuromutilin antibiotic
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)10 ontology terms | Show
+ 23S rRNA with mutation conferring antibiotic resistance
+ determinant of linezolid resistance
+ confers_resistance_to_antibiotic linezolid [Antibiotic]
+ confers_resistance_to_drug_class glycopeptide antibiotic [Drug Class]
+ confers_resistance_to_drug_class streptogramin antibiotic [Drug Class]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_drug_class phenicol antibiotic [Drug Class]
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class]
+ confers_resistance_to_drug_class pleuromutilin antibiotic [Drug Class]
Sub-Term(s)
1 ontology terms | Show
Publications

Musumeci R, et al. 2016. New Microbiol. 39(4):269-273 Resistance to linezolid in Staphylococcus spp. clinical isolates associated with ribosomal binding site modifications: novel mutation in domain V of 23S rRNA. (PMID 27727405)