bleomycin [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:0000053
Synonym(s)Blenoxane Bleocin Bleomicin Bleomycin sulfate cu-blenoxane Isobleomycin A2
DefinitionBleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent.
SMILESCc1c(N)nc([C@H](CC(N)=O)NC[C@H](N)C(N)=O)nc1C(=O)N[C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@H](C(=O)NCCc1nc(-c2nc(C(=O)NCCC[S+](C)C)cs2)cs1)[C@@H](C)O)[C@@H](O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)c1c[nH]cn1
PubChem5360373
ChEMBLCHEMBL403664
ChEBI22907
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
6 ontology terms | Show
+ bleomycinic acid [Antibiotic]
+ bleomycin A2 [Antibiotic]
+ bleomycin B2 [Antibiotic]
+ BLMT confers_resistance_to_antibiotic
+ deoxyribonucleic acid targeted_by_antibiotic
+ ribonucleic acid targeted_by_antibiotic
Publications

Galm U, et al. 2005. Chem Rev 105(2): 739-758. Antitumor antibiotics: bleomycin, enediynes, and mitomycin. (PMID 15700963)

Curator Acknowledgements
Curator Description Most Recent Edit