bleomycin [Antibiotic]

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Accession ARO:0000053
Synonym(s)Blenoxane Bleocin Bleomycin sulfate Bleomicin Isobleomycin A2 cu-blenoxane
DefinitionBleomycin is a family of glycopeptide antibiotics produced by the bacterium Streptomyces verticillus. Bleomycins, taken as a mixture, act by the induction of DNA and RNA strand breaks. In addition to its antibacterial activity, bleomycin is also used as an anticancer agent.
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
6 ontology terms | Show
+ bleomycinic acid [Antibiotic]
+ bleomycin A2 [Antibiotic]
+ bleomycin B2 [Antibiotic]
+ BLMT confers_resistance_to_antibiotic
+ deoxyribonucleic acid targeted_by_antibiotic
+ ribonucleic acid targeted_by_antibiotic

Galm U, et al. 2005. Chem Rev 105(2): 739-758. Antitumor antibiotics: bleomycin, enediynes, and mitomycin. (PMID 15700963)