glycopeptide antibiotic [Drug Class]

Accession ARO:3000081
DefinitionGlycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
36 ontology terms | Show
+ teicoplanin [Antibiotic]
+ vancomycin [Antibiotic]
+ bleomycin
+ antibiotic A47934 [Antibiotic]
+ balhimycin [Antibiotic]
+ chloroeremomycin [Antibiotic]
+ oritavancin [Antibiotic]
+ antibiotic A40926 [Antibiotic]
+ telavancin [Antibiotic]
+ dalbavancin [Antibiotic]
+ ristocetin [Antibiotic]
+ avoparcin [Antibiotic]
+ bleomycinic acid [Antibiotic]
+ bleomycin A2 [Antibiotic]
+ bleomycin B2 [Antibiotic]
+ CBP C1-aminomethylene vancomycin [Antibiotic]
+ eremomycin pyrrolidide [Antibiotic]
+ determinant of resistance to glycopeptide antibiotics confers_resistance_to_drug_class
+ glycopeptide resistance gene cluster [AMR Gene Family] confers_resistance_to_drug_class
+ vanJ membrane protein [AMR Gene Family] confers_resistance_to_drug_class
+ Bleomycin resistant protein [AMR Gene Family] confers_resistance_to_drug_class
+ vanT [AMR Gene Family] confers_resistance_to_drug_class
+ vanH [AMR Gene Family] confers_resistance_to_drug_class
+ vanU [AMR Gene Family] confers_resistance_to_drug_class
+ vanW [AMR Gene Family] confers_resistance_to_drug_class
+ vanX [AMR Gene Family] confers_resistance_to_drug_class
+ vanXY [AMR Gene Family] confers_resistance_to_drug_class
+ vanY [AMR Gene Family] confers_resistance_to_drug_class
+ van ligase [AMR Gene Family] confers_resistance_to_drug_class
+ vanK [AMR Gene Family] confers_resistance_to_drug_class
+ vanV [AMR Gene Family] confers_resistance_to_drug_class
+ vanZ [AMR Gene Family] confers_resistance_to_drug_class
+ vanR [AMR Gene Family] confers_resistance_to_drug_class
+ vanS [AMR Gene Family] confers_resistance_to_drug_class
+ 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ vancomycin-resistant beta prime subunit of RNA polymerase (rpoC) [AMR Gene Family] confers_resistance_to_drug_class
Publications

Donadio S, et al. 2005. Mol Genet Genomics 274(1): 40-50. Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis. (PMID 16007453)

Perkins HR and Nieto M. 1974. Ann N Y Acad Sci 235: 348-363. The chemical basis for the action of the vancomycin group of antibiotics. (PMID 4369274)

Williams DH and Waltho JP. 1988. Biochem Pharmacol 37(1): 133-141. Molecular basis of the activity of antibiotics of the vancomycin group. (PMID 3276316)

Walsh C. 1999. Science 284(5413): 442-443. Deconstructing vancomycin. (PMID 10232990)