| Accession | ARO:3000081 |
| Definition | Glycopeptide antibiotics are natural products produced non-ribosomally by Actinomycetales bacteria. With the exception of bleomycins, they act by binding the terminal D-Ala-D-Ala in peptidoglycan precursors of the growing bacterial cell wall and are generally active against Gram-positive bacteria. This inhibits transglycosylation leading to cell death due to osmotic stress. |
| Classification | 1 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 39 ontology terms | Show + teicoplanin [Antibiotic] + vancomycin [Antibiotic] + bleomycin [Antibiotic] + antibiotic A47934 [Antibiotic] + balhimycin [Antibiotic] + chloroeremomycin [Antibiotic] + oritavancin [Antibiotic] + antibiotic A40926 [Antibiotic] + telavancin [Antibiotic] + dalbavancin [Antibiotic] + ristocetin [Antibiotic] + avoparcin [Antibiotic] + bleomycinic acid [Antibiotic] + bleomycin A2 [Antibiotic] + bleomycin B2 [Antibiotic] + CBP C1-aminomethylene vancomycin [Antibiotic] + eremomycin pyrrolidide [Antibiotic] + complestatin [Antibiotic] + corbomycin [Antibiotic] + norvancomycin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] confers_resistance_to_drug_class + vanJ membrane protein [AMR Gene Family] confers_resistance_to_drug_class + Bleomycin resistant protein [AMR Gene Family] confers_resistance_to_drug_class + vanT [AMR Gene Family] confers_resistance_to_drug_class + vanH [AMR Gene Family] confers_resistance_to_drug_class + vanU [AMR Gene Family] confers_resistance_to_drug_class + vanW [AMR Gene Family] confers_resistance_to_drug_class + vanX [AMR Gene Family] confers_resistance_to_drug_class + vanXY [AMR Gene Family] confers_resistance_to_drug_class + vanY [AMR Gene Family] confers_resistance_to_drug_class + Van ligase [AMR Gene Family] confers_resistance_to_drug_class + vanK [AMR Gene Family] confers_resistance_to_drug_class + vanV [AMR Gene Family] confers_resistance_to_drug_class + vanZ [AMR Gene Family] confers_resistance_to_drug_class + vanR [AMR Gene Family] confers_resistance_to_drug_class + vanS [AMR Gene Family] confers_resistance_to_drug_class + 23S rRNA with mutation conferring resistance to linezolid antibiotics [AMR Gene Family] confers_resistance_to_drug_class + vancomycin-resistant beta prime subunit of RNA polymerase (rpoC) [AMR Gene Family] confers_resistance_to_drug_class + murG transferase [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | Donadio S, et al. 2005. Mol Genet Genomics 274(1): 40-50. Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis. (PMID 16007453) Perkins HR and Nieto M. 1974. Ann N Y Acad Sci 235: 348-363. The chemical basis for the action of the vancomycin group of antibiotics. (PMID 4369274) Williams DH and Waltho JP. 1988. Biochem Pharmacol 37(1): 133-141. Molecular basis of the activity of antibiotics of the vancomycin group. (PMID 3276316) Walsh C. 1999. Science 284(5413): 442-443. Deconstructing vancomycin. (PMID 10232990) |