| Accession | ARO:3002906 |
| Definition | Van ligases synthesize alternative substrates for peptidoglycan synthesis that reduce vancomycin binding affinity. |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic molecule |
| Parent Term(s) | 2 ontology terms | Show + gene(s) or protein(s) associated with a glycopeptide resistance cluster + confers_resistance_to_drug_class glycopeptide antibiotic [Drug Class] |
| Sub-Term(s) | 3 ontology terms | Show |
| Publications | Boyd DA, et al. 2006. Antimicrob Agents Chemother 50(6): 2217-2221. VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada. (PMID 16723588) Boyd DA, et al. 2008. Antimicrob Agents Chemother 52(7): 2667-2672. Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL. (PMID 18458129) Lebreton F, et al. 2011. Antimicrob Agents Chemother 55(10): 4606-4612. D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium. (PMID 21807981) Gudeta DD, et al. 2014. Antimicrob Agents Chemother 58(3): 1768-1770. vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates. (PMID 24342631) Xu X, et al. 2010. Antimicrob Agents Chemother 54(11): 4643-4647. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. (PMID 20733041) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) Fraimow H, et al. 2005. Antimicrob Agents Chemother 49(7): 2625-2633. Putative VanRS-like two-component regulatory system associated with the inducible glycopeptide resistance cluster of Paenibacillus popilliae. (PMID 15980329) Boyd DA, et al. 2002. Antimicrob Agents Chemother 46(6): 1977-1979. Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada. (PMID 12019119) |