Accession | ARO:3002978 |
Definition | A van ligase that synthesizes D-Ala-D-Lac, an alternative peptidoglycan substrate that confers resistance to vancomycin. |
AMR Gene Family | Van ligase |
Drug Class | glycopeptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic molecule + gene(s) or protein(s) associated with a glycopeptide resistance cluster + glycopeptide antibiotic [Drug Class] |
Parent Term(s) | 1 ontology terms | Show + Van ligase [AMR Gene Family] |
Sub-Term(s) | 8 ontology terms | Show |
Publications | Gudeta DD, et al. 2014. Antimicrob Agents Chemother 58(3): 1768-1770. vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates. (PMID 24342631) Xu X, et al. 2010. Antimicrob Agents Chemother 54(11): 4643-4647. vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium. (PMID 20733041) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) Fraimow H, et al. 2005. Antimicrob Agents Chemother 49(7): 2625-2633. Putative VanRS-like two-component regulatory system associated with the inducible glycopeptide resistance cluster of Paenibacillus popilliae. (PMID 15980329) |
Curator | Description | Most Recent Edit |
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