Accession | ARO:3002979 |
Definition | A van ligase that synthesizes D-Ala-D-Ser, an alternative peptidoglycan substrate that confers resistance to vancomycin. |
AMR Gene Family | Van ligase |
Drug Class | glycopeptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic molecule + gene(s) or protein(s) associated with a glycopeptide resistance cluster + glycopeptide antibiotic [Drug Class] |
Parent Term(s) | 1 ontology terms | Show + Van ligase [AMR Gene Family] |
Sub-Term(s) | 5 ontology terms | Show |
Publications | Boyd DA, et al. 2006. Antimicrob Agents Chemother 50(6): 2217-2221. VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada. (PMID 16723588) Lebreton F, et al. 2011. Antimicrob Agents Chemother 55(10): 4606-4612. D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium. (PMID 21807981) Boyd DA, et al. 2008. Antimicrob Agents Chemother 52(7): 2667-2672. Molecular characterization of Enterococcus faecalis N06-0364 with low-level vancomycin resistance harboring a novel D-Ala-D-Ser gene cluster, vanL. (PMID 18458129) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) Meziane-Cherif D, et al. 2012. J Biol Chem 287(45): 37583-37592. Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis. (PMID 22969085) Boyd DA, et al. 2002. Antimicrob Agents Chemother 46(6): 1977-1979. Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada. (PMID 12019119) |
Curator | Description | Most Recent Edit |
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