vanG

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Accession ARO:3002909
CARD Short NamevanG
DefinitionVanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
AMR Gene FamilyVan ligase, glycopeptide resistance gene cluster
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesStreptococcus agalactiaeg, Streptococcus anginosusg, Streptococcus suiswgs
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Acinetobacter calcoaceticuswgs, Acinetobacter haemolyticusg, Anaerostipes hadrusg+wgs, Bacillus cereuswgs, Bacillus pumilusg, Bacillus thuringiensiswgs, Bacteroides ovatuswgs, Brevibacillus brevisg+wgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Clostridium botulinumwgs, Clostridium tetanig+wgs, Cronobacter condimentig+wgs, Cronobacter dublinensisg+wgs, Cronobacter malonaticusg+wgs, Cronobacter sakazakiig+wgs, Cronobacter turicensiswgs, Cronobacter universalisg+wgs, Dysosmobacter welbionisg+wgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenusg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Erysipelatoclostridium ramosumg+wgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Escherichia marmotaeg+wgs, Faecalibacterium prausnitziig+wgs, Herbinix luporumg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatag+wgs, Paeniclostridium sordelliig+wgs, Parabacteroides distasoniswgs, Proteus columbaeg+wgs, Proteus mirabilisg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Providencia alcalifaciensg+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Pseudomonas brassicacearumwgs, Pseudomonas chlororaphisg+wgs, Pseudomonas fluorescensg+wgs, Pseudomonas koreensiswgs, Pseudomonas putidag+wgs, Pseudomonas synxanthag+wgs, Pseudomonas syringaewgs, Raoultella planticolag+wgs, Ruthenibacterium lactatiformansg+wgs, Salmonella bongorig+wgs, Salmonella entericag+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Streptococcus agalactiaeg, Streptococcus anginosusg, Streptococcus suiswgs
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116)

Abadia Patino L, et al. 2002. J Bacteriol 184(23): 6457-6464. vanE gene cluster of vancomycin-resistant Enterococcus faecalis BM4405. (PMID 12426332)
Resistomes

Prevalence of vanG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0%0.01%0%
Acinetobacter calcoaceticus0%0%4.35%0%
Acinetobacter haemolyticus7.14%0%0%0%
Anaerostipes hadrus100%0%46.55%0%
Bacillus cereus0%0%0.1%0%
Bacillus pumilus20%0%0%0%
Bacillus thuringiensis0%0%0.17%0%
Bacteroides ovatus0%0%0.38%0%
Brevibacillus brevis100%0%100%0%
Citrobacter amalonaticus100%0%87.27%0%
Citrobacter freundii100%0.31%50.68%0%
Citrobacter koseri100%0%49.55%0%
Citrobacter portucalensis100%0%61.26%0%
Citrobacter werkmanii100%0%61.54%0%
Citrobacter youngae100%0%100%0%
Clostridium botulinum0%0%0.82%0%
Clostridium tetani100%0%100%0%
Cronobacter condimenti100%0%100%0%
Cronobacter dublinensis100%0%100%0%
Cronobacter malonaticus100%0%85.45%0%
Cronobacter sakazakii100%0%91.7%0%
Cronobacter turicensis0%0%83.33%0%
Cronobacter universalis100%0%100%0%
Dysosmobacter welbionis100%0%100%0%
Enterobacter asburiae100%0%70.75%0%
Enterobacter cancerogenus100%0%100%0%
Enterobacter chengduensis100%0%84%0%
Enterobacter cloacae100%0%73.48%0%
Enterobacter hormaechei98.56%0.19%66.94%0%
Enterobacter kobei100%0%68.56%0%
Enterobacter roggenkampii97.67%0%62.23%0%
Erysipelatoclostridium ramosum100%0%51.16%0%
Escherichia albertii100%0%59.35%0%
Escherichia coli67.75%0.01%61.8%0%
Escherichia fergusonii100%0.36%48.91%0%
Escherichia marmotae100%0%70.83%0%
Faecalibacterium prausnitzii100%0%77.67%0%
Herbinix luporum100%0%100%0%
Klebsiella aerogenes100%0%79.94%0%
Klebsiella huaxiensis100%0%66.67%0%
Klebsiella michiganensis100%0%69.15%0%
Klebsiella oxytoca97.44%0%75.21%0%
Klebsiella pneumoniae99.41%0%57.29%0%
Klebsiella quasipneumoniae100%0%73.82%0%
Kosakonia arachidis100%0%100%0%
Leclercia adecarboxylata100%0%60.47%0%
Paeniclostridium sordellii100%0%96.61%0%
Parabacteroides distasonis0%0%0.93%0%
Proteus columbae100%0%100%0%
Proteus mirabilis100%0%42.08%0%
Proteus penneri100%0%100%0%
Proteus vulgaris100%0%88.89%0%
Providencia alcalifaciens72.73%0%48.28%0%
Providencia heimbachae100%0%71.43%0%
Providencia rettgeri97.06%0%54.14%0%
Providencia stuartii100%0%70.45%0%
Pseudomonas brassicacearum0%0%8%0%
Pseudomonas chlororaphis83.95%0%46.77%0%
Pseudomonas fluorescens47.22%0%36.09%0%
Pseudomonas koreensis0%0%4.35%0%
Pseudomonas putida1.41%0%2.67%0%
Pseudomonas synxantha90.91%0%87.5%0%
Pseudomonas syringae0%0%0.51%0%
Raoultella planticola100%0%94.87%0%
Ruthenibacterium lactatiformans100%0%76.67%0%
Salmonella bongori100%0%94.74%0%
Salmonella enterica95.21%0%80.09%0%
Serratia liquefaciens100%0%50.79%0%
Serratia marcescens97.73%1.29%76.93%0%
Shigella boydii100%0%98.89%0%
Shigella dysenteriae100%0%100%0%
Shigella flexneri98%0%76.09%0%
Shigella sonnei100%0%95.84%0%
Streptococcus agalactiae1.87%0%0%0%
Streptococcus anginosus5.88%0%0%0%
Streptococcus suis0%0%0.26%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 250


>gb|ABA71731.1|+|vanG [Enterococcus faecalis]
MQNKKIAVIFGGNSTEYEVSLQSASAVFENINTNKFDIIPIGITRSGEWYHYTGEKEKILNNTWFEDSKNLCPVVVSQNRSVKGFLEIAS
DKYRIIKVDLVFPVLHGKNGEDGTLQGIFELAGIPVVGCDTLSSALCMDKDRAHKLVSLAGISVPKSVTFKRFNEEAAMKEIEANLTYPL
FIKPVRAGSSFGITKVIEKQELDAAIELAFEHDTEVIVEETINGFEVGCAVLGIDELIVGRVDEIELSSGFFDYTEKYTLKSSKIYMPAR
IDAEAEKRIQEAAVTIYKALGCSGFSRVDMFYTPSGEIVFNEVNTIPGFTSHSRYPNMMKGIGLSFSQMLDKLIGLYVE


>gb|DQ212986.1|+|5985-7034|vanG [Enterococcus faecalis]
ATGCAAAATAAAAAAATAGCAGTTATTTTTGGAGGCAATTCAACAGAGTACGAGGTGTCATTGCAATCGGCATCCGCTGTTTTTGAAAAT
ATCAATACCAATAAATTTGACATAATTCCAATAGGAATTACAAGAAGTGGTGAATGGTATCACTATACGGGAGAAAAGGAGAAAATCCTA
AACAATACTTGGTTTGAAGATAGCAAAAATCTATGCCCTGTTGTCGTTTCCCAAAATCGTTCCGTTAAAGGCTTTTTAGAAATTGCTTCA
GACAAATACCGTATTATAAAAGTTGATTTGGTATTCCCCGTATTGCATGGCAAAAACGGCGAAGATGGTACTTTGCAGGGCATATTTGAA
TTGGCAGGAATACCTGTTGTTGGCTGCGATACACTCTCATCAGCTCTTTGTATGGATAAGGACAGGGCACATAAACTCGTTAGCCTTGCG
GGTATATCTGTTCCTAAATCGGTAACATTCAAACGCTTTAACGAAGAAGCAGCGATGAAAGAGATTGAAGCGAATTTAACTTATCCGCTG
TTTATTAAACCTGTTCGTGCAGGCTCTTCCTTTGGAATAACAAAAGTAATTGAAAAGCAAGAGCTTGATGCTGCCATAGAGTTGGCATTT
GAACACGATACAGAAGTCATCGTTGAAGAAACAATAAACGGCTTTGAAGTCGGTTGTGCCGTACTTGGCATAGATGAGCTCATTGTTGGC
AGAGTTGATGAAATCGAACTGTCAAGCGGCTTTTTTGATTATACAGAGAAATATACGCTTAAATCTTCAAAGATATATATGCCTGCAAGG
ATTGATGCCGAAGCAGAAAAACGGATACAAGAAGCGGCTGTAACCATATATAAAGCTCTGGGCTGTTCGGGTTTTTCCAGAGTGGATATG
TTTTATACACCGTCTGGCGAAATTGTATTTAATGAGGTAAACACAATACCAGGCTTTACCTCGCACAGTCGCTATCCAAATATGATGAAA
GGCATTGGTCTATCGTTCTCCCAAATGTTGGATAAGCTGATAGGTCTGTATGTGGAATGA