| Accession | ARO:3000257 |
| CARD Short Name | vanG_cluster |
| Definition | Contains a D-Ala-D-Ser ligase. The vanG gene cluster is inducible and confers low resistance to vancomycin. vanG organisms remain susceptible to teicoplanin. It is the only van gene cluster that contains two vanY genes. Gene orientation: vanRSYWGYT. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + antibiotic molecule + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon + restructuring of bacterial cell wall conferring antibiotic resistance |
| Parent Term(s) | 2 ontology terms | Show + glycopeptide resistance gene cluster [AMR Gene Family] + confers_resistance_to_antibiotic vancomycin [Antibiotic] |
| Sub-Term(s) | 8 ontology terms | Show + vanG part_of + vanR gene in vanG cluster part_of + vanS gene in vanG cluster part_of + vanT gene in vanG cluster part_of + vanW gene in vanG cluster part_of + vanY gene in vanG cluster part_of + vanXY gene in vanG cluster part_of + vanU gene in vanG cluster part_of |
| Publications | Weber P, et al. 2009. Acta Crystallogr Sect F Struct Biol Cryst Commun 65(PT 10): 1024-1026. Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance. (PMID 19851013) McKessar SJ, et al. 2000. Antimicrob Agents Chemother 44(11): 3224-3228. Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis. (PMID 11036060) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) |
Prevalence of glycopeptide resistance gene cluster VanG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster VanG
Model Description:
Regulatory: vanUvanR gene in vanG clustervanS gene in vanG cluster
Core: vanGvanT gene in vanG clustervanXY gene in vanG cluster
Accessory: vanY gene in vanG clustervanW gene in vanG cluster