| Accession | ARO:3002965 |
| Synonym(s) | vanWG vanW-G |
| CARD Short Name | vanW_in_vanG_cl |
| Definition | Also known as vanWG, is a vanW variant found in the vanG gene cluster. |
| AMR Gene Family | glycopeptide resistance gene cluster, vanW |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Streptococcus agalactiaeg, Streptococcus anginosusg |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Acinetobacter calcoaceticuswgs, Acinetobacter johnsoniig+wgs, Acinetobacter juniiwgs, Acinetobacter lwoffiiwgs, Bacillus anthraciswgs, Bacillus cereusg+wgs, Bacillus thuringiensisg+wgs, Brevibacillus brevisg+wgs, Brevibacillus laterosporusg+wgs, Chryseobacterium nakagawaig+wgs, Elizabethkingia anophelisg+wgs, Elizabethkingia miricolag+wgs, Enterococcus faecalisg+wgs, Klebsiella pneumoniaewgs, Kocuria palustrisg+wgs, Leminorella grimontiiwgs, Paenibacillus mucilaginosusg+wgs, Porphyromonas gingivalisg+wgs, Proteus columbaeg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas brassicacearumwgs, Pseudomonas chlororaphiswgs, Pseudomonas fluorescensg+wgs, Pseudomonas koreensisg+wgs, Pseudomonas putidag+wgs, Pseudomonas syringaeg+wgs, Ruthenibacterium lactatiformansg+wgs, Staphylococcus arlettaewgs, Staphylococcus aureusg+wgs, Staphylococcus epidermidiswgs, Staphylococcus equorumwgs, Staphylococcus haemolyticuswgs, Staphylococcus saprophyticuswgs, Staphylococcus simulansg+wgs, Staphylococcus warnerig+p+wgs, Streptococcus agalactiaeg+wgs, Streptococcus anginosusg, Streptococcus gwangjuenseg, Streptococcus lutetiensisg+wgs, Streptococcus mitisg+wgs, Streptococcus pseudopneumoniaewgs, Streptococcus suiswgs, Treponema denticolag, Xanthomonas campestrisg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + restructuring of bacterial cell wall conferring antibiotic resistance + antibiotic resistance gene cluster, cassette, or operon + glycopeptide antibiotic [Drug Class] + protein(s) conferring antibiotic resistance via molecular bypass + gene(s) or protein(s) associated with a glycopeptide resistance cluster + glycopeptide resistance gene cluster [AMR Gene Family] + vancomycin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Boyd DA, et al. 2006. Antimicrob Agents Chemother 50(6): 2217-2221. VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada. (PMID 16723588) |
Prevalence of vanW gene in vanG cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.04% | 0% |
| Acinetobacter calcoaceticus | 0% | 0% | 4.35% | 0% |
| Acinetobacter johnsonii | 89.47% | 0% | 69.09% | 0% |
| Acinetobacter junii | 0% | 0% | 7.46% | 0% |
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Bacillus anthracis | 0% | 0% | 0.44% | 0% |
| Bacillus cereus | 34.41% | 0% | 58.33% | 0% |
| Bacillus thuringiensis | 76.25% | 0% | 82.72% | 0% |
| Brevibacillus brevis | 14.29% | 0% | 30% | 0% |
| Brevibacillus laterosporus | 33.33% | 0% | 20.59% | 0% |
| Chryseobacterium nakagawai | 100% | 0% | 100% | 0% |
| Elizabethkingia anophelis | 100% | 0% | 67.01% | 0% |
| Elizabethkingia miricola | 100% | 0% | 82.61% | 0% |
| Enterococcus faecalis | 0.45% | 0% | 0.12% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Kocuria palustris | 100% | 0% | 61.11% | 0% |
| Leminorella grimontii | 0% | 0% | 85.71% | 0% |
| Paenibacillus mucilaginosus | 100% | 0% | 100% | 0% |
| Porphyromonas gingivalis | 100% | 0% | 65.52% | 0% |
| Proteus columbae | 100% | 0% | 100% | 0% |
| Proteus penneri | 100% | 0% | 100% | 0% |
| Proteus vulgaris | 100% | 0% | 88.89% | 0% |
| Providencia heimbachae | 100% | 0% | 71.43% | 0% |
| Providencia rettgeri | 50% | 0% | 31.21% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 99.54% | 0.29% | 68.23% | 0% |
| Pseudomonas brassicacearum | 0% | 0% | 4% | 0% |
| Pseudomonas chlororaphis | 0% | 0% | 3.23% | 0% |
| Pseudomonas fluorescens | 25% | 0% | 12.17% | 0% |
| Pseudomonas koreensis | 75% | 0% | 56.52% | 0% |
| Pseudomonas putida | 1.41% | 0% | 1.07% | 0% |
| Pseudomonas syringae | 2.08% | 0% | 0.17% | 0% |
| Ruthenibacterium lactatiformans | 100% | 0% | 76.67% | 0% |
| Staphylococcus arlettae | 0% | 0% | 22.5% | 0% |
| Staphylococcus aureus | 0.09% | 0% | 0.11% | 0% |
| Staphylococcus epidermidis | 0% | 0% | 2.59% | 0% |
| Staphylococcus equorum | 0% | 0% | 16.07% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 3.52% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 0.7% | 0% |
| Staphylococcus simulans | 50% | 0% | 69.49% | 0% |
| Staphylococcus warneri | 50% | 2.5% | 48.36% | 0% |
| Streptococcus agalactiae | 1.87% | 0% | 0.06% | 0% |
| Streptococcus anginosus | 5.88% | 0% | 0% | 0% |
| Streptococcus gwangjuense | 100% | 0% | 0% | 0% |
| Streptococcus lutetiensis | 100% | 0% | 20.41% | 0% |
| Streptococcus mitis | 11.11% | 0% | 10.1% | 0% |
| Streptococcus pseudopneumoniae | 0% | 0% | 7.63% | 0% |
| Streptococcus suis | 0% | 0% | 0.26% | 0% |
| Treponema denticola | 6.67% | 0% | 0% | 0% |
| Xanthomonas campestris | 1.06% | 0% | 0.79% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 50