| Accession | ARO:3004253 |
| Synonym(s) | vanUG |
| CARD Short Name | vanU_in_vanG_cl |
| Definition | Also known as vanUG, is a vanG variant found in the vanG gene cluster. |
| AMR Gene Family | glycopeptide resistance gene cluster, vanU |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Perfect Matches | Clostridioides difficilewgs, Streptococcus agalactiaeg, Streptococcus anginosusg |
| Resistomes with Sequence Variants | Clostridioides difficilewgs, Streptococcus agalactiaeg, Streptococcus anginosusg |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + glycopeptide antibiotic [Drug Class] + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic resistance gene cluster, cassette, or operon + glycopeptide resistance gene cluster [AMR Gene Family] + gene(s) or protein(s) associated with a glycopeptide resistance cluster |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Boyd DA, et al. 2006. Antimicrob Agents Chemother 50(6): 2217-2221. VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada. (PMID 16723588) Depardieu F, et al. 2003. Mol Microbiol 50(3): 931-948. The vanG glycopeptide resistance operon from Enterococcus faecalis revisited. (PMID 14617152) McKessar SJ, et al. 2000. Antimicrob Agents Chemother 44(11): 3224-3228. Genetic characterization of vanG, a novel vancomycin resistance locus of Enterococcus faecalis. (PMID 11036060) |
Prevalence of vanU gene in vanG cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Clostridioides difficile | 0% | 0% | 0.19% | 0% |
| Streptococcus agalactiae | 1.18% | 0% | 0% | 0% |
| Streptococcus anginosus | 9.09% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 125