vanT gene in vanG cluster

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Accession ARO:3002972
Synonym(s)vanT-G vanTG
CARD Short NamevanT_in_vanG_cl
DefinitionAlso known as vanTG, is a vanT variant found in the vanG gene cluster.
AMR Gene Familyglycopeptide resistance gene cluster, vanT
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Perfect MatchesStreptococcus agalactiaeg, Streptococcus anginosusg, Streptococcus suiswgs
Resistomes with Sequence VariantsAeromonas enteropelogenesg+wgs, Alistipes putrediniswgs, Alloiococcus otitiswgs, Anaerococcus mediterraneensisg, Anaerostipes hadrusg+wgs, Bacillus amyloliquefaciensg+wgs, Bacillus anthracisg+wgs, Bacillus cereusg+wgs, Bacillus halotoleransg+wgs, Bacillus pumilusg+wgs, Bacillus subtilisg+wgs, Bacillus tequilensisg+wgs, Bacillus thuringiensisg+wgs, Bacillus velezensisg+wgs, Bacteroides caccaeg+wgs, Bacteroides fragilisg+wgs, Bacteroides ovatusg+wgs, Bacteroides thetaiotaomicrong+wgs, Blautia productag+wgs, Borrelia hermsiig, Borrelia miyamotoig, Borreliella afzeliig, Borreliella gariniig+wgs, Brachyspira pilosicolig+wgs, Brevibacillus brevisg+wgs, Brevibacillus laterosporusg+wgs, Burkholderia latawgs, Campylobacter ureolyticusg+wgs, Capnocytophaga gingivalisg+wgs, Capnocytophaga ochraceag+wgs, Capnocytophaga sputigenag+wgs, Christensenella minutag+wgs, Chryseobacterium nakagawaig+wgs, Chryseobacterium taklimakanenseg+wgs, Clostridium botulinumg+wgs, Clostridium butyricumg+wgs, Clostridium perfringensg+wgs, Clostridium septicumg+wgs, Clostridium sporogenesg+wgs, Clostridium tetanig+wgs, Collinsella aerofaciensg+wgs, Corynebacterium pseudotuberculosisg+wgs, Corynebacterium ulceransg+wgs, Coxiella burnetiig+wgs, Cryptobacterium curtumg, Cutibacterium acnesg+wgs, Cytophaga hutchinsoniig+wgs, Dysosmobacter welbionisg+wgs, Elizabethkingia anophelisg+wgs, Elizabethkingia miricolag+wgs, Enterocloster clostridioformisg+wgs, Enterococcus aviumwgs, Enterococcus faecalisg+wgs, Erysipelatoclostridium ramosumg+wgs, Erysipelothrix rhusiopathiaeg+wgs, Eubacterium limosumg+wgs, Eubacterium maltosivoransg+wgs, Faecalibacterium prausnitziig+wgs, Fusobacterium necrophorumg+wgs, Fusobacterium nucleatumg+wgs, Fusobacterium periodonticumg+wgs, Gemella morbillorumg+wgs, Gordonibacter urolithinfaciensg+wgs, Helicobacter pylorig+wgs, Herbinix luporumg+wgs, Jeotgalibaca porcig, Lachnoclostridium phocaeenseg, Lactobacillus gasserig+wgs, Lactococcus garvieaeg+wgs, Lancefieldella rimaewgs, Leptospira borgpeterseniig+wgs, Leptospira interrogansg+p+wgs, Leptospira santarosaig+wgs, Ligilactobacillus animalisg+wgs, Listeria innocuag+wgs, Listeria monocytogenesg+p+wgs, Lysobacter oculig, Macrococcus canisg+wgs, Massilistercora timonensisg, Megasphaera stantoniig+wgs, Myroides odoratimimusg+wgs, Myroides phaeusg+wgs, Nitrosomonas europaeag+wgs, Paenibacillus mucilaginosusg+wgs, Paeniclostridium sordelliig+wgs, Parabacteroides distasonisg+wgs, Parvimonas micrag+wgs, Peptacetobacter hiranonisg+wgs, Peptoniphilus hareig+wgs, Phocaeicola doreig+wgs, Phocaeicola massiliensiswgs, Phocaeicola vulgatusg+wgs, Phoenicibacter congonensisg, Porphyromonas gingivalisg+wgs, Prevotella biviawgs, Prevotella intermediag+wgs, Propionibacterium freudenreichiig+wgs, Proteus vulgarisg+wgs, Providencia alcalifacienswgs, Providencia rettgerig+wgs, Providencia stuartiiwgs, Pseudoleptotrichia goodfellowiig+wgs, Pseudomonas aeruginosawgs, Pseudomonas fluorescenswgs, Pseudomonas monteiliig, Pseudomonas putidag+wgs, Riemerella anatipestiferg+p+wgs, Roseburia hominiswgs, Ruthenibacterium lactatiformansg+wgs, Sphingobacterium hotanenseg+wgs, Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+p+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus equorumg+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominisg+wgs, Staphylococcus massiliensiswgs, Staphylococcus pasteurig+wgs, Staphylococcus saprophyticusg+wgs, Staphylococcus schleiferig+wgs, Staphylococcus simulansg+wgs, Staphylococcus warnerig+wgs, Streptococcus agalactiaeg+wgs, Streptococcus anginosusg+wgs, Streptococcus constellatusg+wgs, Streptococcus cristatuswgs, Streptococcus equig+wgs, Streptococcus gallolyticusg+wgs, Streptococcus gordoniig+wgs, Streptococcus gwangjuenseg, Streptococcus intermediusg+wgs, Streptococcus lutetiensisg+wgs, Streptococcus mitisg+wgs, Streptococcus mutansg+wgs, Streptococcus pasteurianusg+wgs, Streptococcus pneumoniaewgs, Streptococcus porcinusg+wgs, Streptococcus pseudopneumoniaeg+wgs, Streptococcus pseudoporcinusg+wgs, Streptococcus pyogenesg+wgs, Streptococcus sanguinisg+wgs, Streptococcus sobrinuswgs, Streptococcus suisg+wgs, Streptococcus uberisg+wgs, Streptococcus urinalisg+wgs, Tannerella forsythiag+wgs, Treponema denticolag+wgs, Treponema pallidumg+wgs, Vibrio alginolyticusg+wgs, Vibrio harveyig+wgs, Vibrio neocaledonicusg, Vibrio owensiig+wgs, Vibrio parahaemolyticusg+wgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ part_of glycopeptide resistance gene cluster VanG
+ vanT [AMR Gene Family]
Publications

Boyd DA, et al. 2006. Antimicrob Agents Chemother 50(6): 2217-2221. VanG-type vancomycin-resistant Enterococcus faecalis strains isolated in Canada. (PMID 16723588)
Resistomes

Prevalence of vanT gene in vanG cluster among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Aeromonas enteropelogenes100%0%75%0%
Alistipes putredinis0%0%92%0%
Alloiococcus otitis0%0%100%0%
Anaerococcus mediterraneensis100%0%0%0%
Anaerostipes hadrus100%0%48.28%0%
Bacillus amyloliquefaciens100%0%83.15%0%
Bacillus anthracis100%0%78.07%0%
Bacillus cereus100%0%85.54%0%
Bacillus halotolerans100%0%89.19%0%
Bacillus pumilus100%0%52.51%0%
Bacillus subtilis99.64%0%78.9%0%
Bacillus tequilensis100%0%100%0%
Bacillus thuringiensis100%0%90.58%0%
Bacillus velezensis100%0%83.52%0%
Bacteroides caccae100%0%95%0%
Bacteroides fragilis100%0%54.91%0%
Bacteroides ovatus100%0%44.87%0%
Bacteroides thetaiotaomicron100%0%42.66%0%
Blautia producta100%0%90.91%0%
Borrelia hermsii100%0%0%0%
Borrelia miyamotoi100%0%0%0%
Borreliella afzelii100%0%0%0%
Borreliella garinii98.59%0%10.71%0%
Brachyspira pilosicoli100%0%100%0%
Brevibacillus brevis100%0%100%0%
Brevibacillus laterosporus100%0%79.41%0%
Burkholderia lata0%0%6.25%0%
Campylobacter ureolyticus100%0%34.48%0%
Capnocytophaga gingivalis100%0%100%0%
Capnocytophaga ochracea100%0%100%0%
Capnocytophaga sputigena100%0%100%0%
Christensenella minuta100%0%100%0%
Chryseobacterium nakagawai100%0%100%0%
Chryseobacterium taklimakanense100%0%100%0%
Clostridium botulinum97.01%0%57.61%0%
Clostridium butyricum66.67%0%82.35%0%
Clostridium perfringens100%0%48.66%0%
Clostridium septicum100%0%100%0%
Clostridium sporogenes100%0%91.45%0%
Clostridium tetani100%0%100%0%
Collinsella aerofaciens83.33%0%44.03%0%
Corynebacterium pseudotuberculosis100%0%55.56%0%
Corynebacterium ulcerans100%0%77.27%0%
Coxiella burnetii100%0%43.93%0%
Cryptobacterium curtum100%0%0%0%
Cutibacterium acnes15%0%19.58%0%
Cytophaga hutchinsonii100%0%100%0%
Dysosmobacter welbionis100%0%100%0%
Elizabethkingia anophelis100%0%67.01%0%
Elizabethkingia miricola100%0%82.61%0%
Enterocloster clostridioformis100%0%62.79%0%
Enterococcus avium0%0%5.26%0%
Enterococcus faecalis97.73%0%43.54%0%
Erysipelatoclostridium ramosum100%0%51.16%0%
Erysipelothrix rhusiopathiae100%0%80%0%
Eubacterium limosum100%0%100%0%
Eubacterium maltosivorans100%0%100%0%
Faecalibacterium prausnitzii93.33%0%79.61%0%
Fusobacterium necrophorum40%0%23.26%0%
Fusobacterium nucleatum100%0%73.53%0%
Fusobacterium periodonticum100%0%85.71%0%
Gemella morbillorum100%0%50%0%
Gordonibacter urolithinfaciens100%0%100%0%
Helicobacter pylori76.92%0%56.94%0%
Herbinix luporum100%0%100%0%
Jeotgalibaca porci100%0%0%0%
Lachnoclostridium phocaeense100%0%0%0%
Lactobacillus gasseri100%0%94.23%0%
Lactococcus garvieae100%0%91.11%0%
Lancefieldella rimae0%0%100%0%
Leptospira borgpetersenii2.38%0%3.12%0%
Leptospira interrogans48.96%2.63%91.61%0%
Leptospira santarosai50%0%14.71%0%
Ligilactobacillus animalis100%0%100%0%
Listeria innocua100%0%39.85%0%
Listeria monocytogenes99.16%0.97%74.47%0%
Lysobacter oculi100%0%0%0%
Macrococcus canis100%0%100%0%
Massilistercora timonensis100%0%0%0%
Megasphaera stantonii100%0%100%0%
Myroides odoratimimus100%0%78.57%0%
Myroides phaeus100%0%100%0%
Nitrosomonas europaea100%0%100%0%
Paenibacillus mucilaginosus100%0%100%0%
Paeniclostridium sordellii100%0%96.61%0%
Parabacteroides distasonis100%0%66.36%0%
Parvimonas micra100%0%62.5%0%
Peptacetobacter hiranonis100%0%100%0%
Peptoniphilus harei100%0%100%0%
Phocaeicola dorei100%0%78.12%0%
Phocaeicola massiliensis0%0%96.15%0%
Phocaeicola vulgatus100%0%51.53%0%
Phoenicibacter congonensis100%0%0%0%
Porphyromonas gingivalis100%0%68.97%0%
Prevotella bivia0%0%100%0%
Prevotella intermedia53.85%0%86.96%0%
Propionibacterium freudenreichii92.59%0%97.44%0%
Proteus vulgaris18.18%0%5.56%0%
Providencia alcalifaciens0%0%3.45%0%
Providencia rettgeri52.94%0%24.2%0%
Providencia stuartii0%0%2.27%0%
Pseudoleptotrichia goodfellowii100%0%100%0%
Pseudomonas aeruginosa0%0%0.01%0%
Pseudomonas fluorescens0%0%1.3%0%
Pseudomonas monteilii22.22%0%0%0%
Pseudomonas putida7.04%0%2.67%0%
Riemerella anatipestifer88.89%30.77%43.75%0%
Roseburia hominis0%0%22.22%0%
Ruthenibacterium lactatiformans100%0%76.67%0%
Sphingobacterium hotanense100%0%100%0%
Staphylococcus arlettae100%0%85%0%
Staphylococcus aureus99.74%0.04%56.09%0%
Staphylococcus epidermidis100%0%71.13%0%
Staphylococcus equorum91.67%0%83.93%0%
Staphylococcus haemolyticus100%0%62.2%0%
Staphylococcus hominis100%0%65.37%0%
Staphylococcus massiliensis0%0%57.14%0%
Staphylococcus pasteuri100%0%96.15%0%
Staphylococcus saprophyticus47.06%0%37.06%0%
Staphylococcus schleiferi100%0%40.91%0%
Staphylococcus simulans100%0%98.31%0%
Staphylococcus warneri100%0%68.85%0%
Streptococcus agalactiae95.33%0%76.68%0%
Streptococcus anginosus100%0%50.88%0%
Streptococcus constellatus100%0%86.36%0%
Streptococcus cristatus0%0%8.57%0%
Streptococcus equi100%0%75.23%0%
Streptococcus gallolyticus100%0%61.36%0%
Streptococcus gordonii100%0%65.38%0%
Streptococcus gwangjuense100%0%0%0%
Streptococcus intermedius100%0%86.36%0%
Streptococcus lutetiensis100%0%44.9%0%
Streptococcus mitis88.89%0%62.63%0%
Streptococcus mutans73.08%0%73.83%0%
Streptococcus pasteurianus100%0%80%0%
Streptococcus pneumoniae0%0%0.26%0%
Streptococcus porcinus100%0%100%0%
Streptococcus pseudopneumoniae100%0%69.49%0%
Streptococcus pseudoporcinus100%0%100%0%
Streptococcus pyogenes19.03%0%5.15%0%
Streptococcus sanguinis28.57%0%5.15%0%
Streptococcus sobrinus0%0%4.08%0%
Streptococcus suis1.6%0%0.89%0%
Streptococcus uberis100%0%41.96%0%
Streptococcus urinalis100%0%100%0%
Tannerella forsythia100%0%100%0%
Treponema denticola100%0%41.18%0%
Treponema pallidum100%0%44.44%0%
Vibrio alginolyticus49.38%0%25.79%0%
Vibrio harveyi50%0%80%0%
Vibrio neocaledonicus50%0%0%0%
Vibrio owensii50%0%84.21%0%
Vibrio parahaemolyticus49.35%0%74.14%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 175


>gb|ABA71733.1|+|vanT gene in vanG cluster [Enterococcus faecalis]
MTKNESYSGIDYFRFIAALLIVAIHTSPLSSFSETGNFIFTRIVARVAVPFFFMTSGFFLISRYTCNAEKLGAFIKKTTLIYGVAILLYI
PINVYNGYFKMDNLLPNIIKDIVFDGTLYHLWYLPASIIGAAIAWYLVKKVHYRKAFLIASILYIIGLFGDSYYGIVKSVSCLNVFYNLI
FQLTDYTRNGIFFAPIFFVLGGYISDSQNRLSLKRSIVGFIVCFALMFGEALTLHHFDIQKHDSMYVLLLPSVYCLFNLLLHFRGKRRTG
LRTISLIIYIIHPFMIVVIRLFAKLLHLQSLLVENSLVHYIAVCFASVVLAVVITALLSSLKPKKAKHTADTDRAYLEINLNNLEHNVNT
LQKAMSPKCELMAVVKAEAYGHGMYEVTTYLEQIGVSSFAVATIDEGIRLRKYGISSEILILGYTSPSRAKELCKYELTQTLIDYRYSLL
LNKQGYDIKAHIKIDTGMHRLGFSTEDKDKILAAFSLKHIKVAGIFTHLCAADSLEENDVAFTNKQIGSFYKVLDWLKSSGLNIPKVHIQ
SSYGLLNYPELECDYIRVGVALYGVLSSTNDKTKLELDLRPVLSLKAKVVLIRKIKQGESVGYSRAFTATRDSLIAILPIGYADGFPRNL
SCGNSYVLIGGRQAPIVGKICMDQLAVDVTDIPNVKTGSIATLIGKDGKEEITAPMVAESAESITNELLSRMGHRLNIIRRA


>gb|DQ212986.1|+|7788-9926|vanT gene in vanG cluster [Enterococcus faecalis]
ATGACTAAAAACGAAAGCTATTCTGGCATTGATTATTTTAGATTTATTGCAGCCTTATTGATTGTTGCTATTCATACTTCGCCTCTCTCT
TCTTTTAGTGAAACAGGCAACTTTATATTTACACGCATTGTAGCCCGTGTAGCCGTTCCGTTCTTTTTTATGACATCTGGATTTTTTCTG
ATTTCCAGATATACCTGTAATGCCGAAAAGCTGGGAGCTTTTATAAAAAAGACAACCTTAATTTACGGGGTTGCAATACTCTTATACATA
CCTATCAATGTTTATAACGGTTATTTCAAAATGGACAACCTTTTGCCAAATATCATAAAAGATATTGTATTTGATGGTACTTTATATCAC
TTGTGGTATCTTCCTGCATCTATTATCGGAGCTGCGATTGCTTGGTATCTGGTAAAGAAAGTTCATTATCGCAAAGCCTTTTTGATAGCT
TCTATACTCTATATCATAGGCTTATTTGGAGATAGTTATTATGGAATTGTGAAAAGCGTTTCCTGCTTAAATGTTTTTTACAATCTAATC
TTCCAATTAACAGATTACACAAGAAACGGAATATTTTTTGCCCCAATCTTTTTTGTGCTTGGTGGATATATCTCTGATAGTCAAAACAGA
CTATCGTTAAAAAGAAGTATAGTAGGATTTATAGTTTGTTTTGCCCTTATGTTTGGAGAAGCCCTTACTTTACATCATTTTGATATACAG
AAACATGACAGTATGTATGTGCTTTTACTTCCGAGTGTGTATTGCTTATTTAATCTTCTTCTGCACTTTAGAGGAAAACGCCGCACAGGA
TTACGGACAATATCATTGATTATCTATATCATTCATCCGTTTATGATTGTTGTAATACGATTGTTTGCCAAATTACTGCATCTGCAAAGC
CTGCTTGTTGAAAACAGCCTTGTTCATTATATTGCGGTCTGCTTTGCATCGGTAGTATTAGCAGTGGTTATAACAGCGTTATTGAGCAGT
CTGAAACCGAAAAAGGCAAAACATACCGCCGATACGGATAGAGCGTATCTGGAAATCAACCTAAATAATTTAGAGCATAATGTAAACACT
TTGCAAAAAGCAATGTCACCTAAATGTGAATTGATGGCGGTTGTAAAAGCGGAAGCCTATGGTCACGGTATGTATGAAGTGACGACATAT
CTTGAGCAGATAGGAGTTTCTTCATTTGCGGTAGCTACCATTGATGAAGGTATCCGATTGAGAAAATATGGCATCTCTAGCGAAATCCTA
ATTTTAGGCTATACATCGCCTTCAAGGGCAAAAGAACTTTGTAAGTATGAGCTGACACAAACCTTGATAGATTATAGGTATTCGTTGCTT
TTGAATAAACAGGGATATGACATTAAAGCACATATTAAAATTGACACAGGTATGCATAGACTTGGATTTAGCACAGAAGATAAGGATAAA
ATCCTTGCAGCTTTTTCTTTGAAGCACATCAAAGTTGCGGGAATTTTTACACATTTGTGTGCGGCTGACAGCCTTGAAGAAAATGATGTT
GCATTTACAAACAAGCAAATAGGCAGTTTCTATAAAGTGCTTGATTGGCTGAAAAGCAGCGGTTTGAATATACCTAAAGTACATATCCAA
AGTAGTTATGGATTATTGAATTATCCAGAGCTTGAATGTGATTATATCAGAGTGGGTGTTGCTCTGTATGGTGTTTTAAGCTCTACTAAT
GACAAAACAAAATTAGAACTTGATTTAAGACCTGTACTTTCTTTGAAAGCAAAAGTTGTTTTAATTCGGAAGATAAAGCAGGGCGAAAGT
GTTGGTTATAGCAGGGCTTTTACTGCAACCCGAGATAGTTTAATTGCCATATTACCAATTGGATATGCAGATGGTTTTCCAAGAAATCTG
TCTTGTGGAAATAGTTATGTGCTGATTGGTGGACGACAAGCCCCTATTGTCGGAAAAATCTGTATGGATCAACTTGCAGTTGATGTAACA
GATATTCCCAATGTTAAGACTGGAAGTATTGCAACGCTGATTGGTAAAGATGGAAAGGAAGAAATTACAGCACCGATGGTAGCTGAAAGT
GCAGAAAGCATAACCAATGAATTGTTAAGCCGTATGGGACACAGATTAAATATTATTCGTAGAGCGTAA