Accession | ARO:3000372 |
Definition | VanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum. |
Drug Class | glycopeptide antibiotic |
Resistance Mechanism | antibiotic target alteration |
Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + determinant of antibiotic resistance + protein(s) conferring antibiotic resistance via molecular bypass + antibiotic molecule |
Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_drug_class glycopeptide antibiotic [Drug Class] + gene(s) or protein(s) associated with a glycopeptide resistance cluster |
Sub-Term(s) | 6 ontology terms | Show |
Publications | Arias CA, et al. 2000. Antimicrob Agents Chemother 44(6): 1660-1666. vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174. (PMID 10817725) Arias CA, et al. 2000. Microbiology 146(PT 7): 1727-1734. Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174. (PMID 10878136) |
Curator | Description | Most Recent Edit |
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