vanT [AMR Gene Family]

Accession ARO:3000372
DefinitionVanT is a membrane bound serine racemase, converting L-serine to D-serine. It is associated with VanC, which incorporated D-serine into D-Ala-D-Ser terminal end of peptidoglycan subunits that have a decreased binding affinity with vancomycin. It was isolated from Enterococcus gallinarum.
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
6 ontology terms | Show

Arias CA, et al. 2000. Antimicrob Agents Chemother 44(6): 1660-1666. vanC cluster of vancomycin-resistant Enterococcus gallinarum BM4174. (PMID 10817725)

Arias CA, et al. 2000. Microbiology 146(PT 7): 1727-1734. Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174. (PMID 10878136)