vanK [AMR Gene Family]

Accession ARO:3002915
DefinitionVanK is a member of the Fem family of enzymes that add the cross-bridge amino acids to the stem pentapeptide of cell wall precursors in Streptomyces coelicolor that confers inducible, high-level vancomycin resistance.
Drug Classglycopeptide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Sub-Term(s)
1 ontology terms | Show
Publications

Hong HJ, et al. 2004. Mol Microbiol 52(4): 1107-1121. Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance. (PMID 15130128)

Hong HJ, et al. 2005. J Biol Chem 280(13): 13055-13061. The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor. (PMID 15632111)

Curator Acknowledgements
Curator Description Most Recent Edit