ristocetin [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000022
DefinitionRistocetin is a glycopeptide antibiotic similar to vancomycin but positively charged. It is not used clinically because it induces platelet agglutination.
SMILESCc1c(O)cc2cc1Oc1cc(ccc1O)[C@@H](N)C(=O)N[C@H]1C(=O)N[C@@H]2C(=O)N[C@H]2C(=O)N[C@H]3C(=O)N[C@H](C(=O)N[C@@H](C(=O)O)c4cc(O)cc(O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)c4-c4cc3ccc4O)[C@H](O[C@H]3C[C@@H](N)[C@@H](O)[C@H](C)O3)c3ccc(cc3)Oc3cc2cc(c3O[C@H]2O[C@@H](CO[C@H]3O[C@H](C)[C@@H](O)[C@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)Oc2ccc(cc2)[C@H]1O
PubChem16204749
ChEBI85129
CAS1404-55-3
ChEMBLCHEMBL1095986
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
1 ontology terms | Show
+ acyl-D-alanyl-D-alanine targeted_by_antibiotic
Publications

Coller BS and Gralnick HR. 1977. J Clin Invest 60(2): 302-312. Studies on the mechanism of ristocetin-induced platelet agglutination. Effects of structural modification of ristocetin and vancomycin. (PMID 17620)

Reynolds PE. 1989. Eur J Clin Microbiol Infect Dis 8(11): 943-950. Structure, biochemistry and mechanism of action of glycopeptide antibiotics. (PMID 2532132)

Curator Acknowledgements
Curator Description Most Recent Edit