Accession ARO:3000720
DefinitionThe acyl-D-alanyl-D-alanine group is found at the terminal end of the pentapeptide chains of peptidoglycan subunits. Antibiotics that bind to this group block the addition of subunits, inhibiting peptidoglycan synthesis. This group is most accessible in Gram-postive bacteria.
Classification2 ontology terms | Show
Parent Term(s)12 ontology terms | Show
+ targeted_by_antibiotic teicoplanin [Antibiotic]
+ targeted_by_antibiotic vancomycin [Antibiotic]
+ targeted_by_antibiotic dalbavancin [Antibiotic]
+ targeted_by_antibiotic telavancin [Antibiotic]
+ targeted_by_antibiotic oritavancin [Antibiotic]
+ targeted_by_antibiotic chloroeremomycin [Antibiotic]
+ targeted_by_antibiotic balhimycin [Antibiotic]
+ targeted_by_antibiotic antibiotic A47934 [Antibiotic]
+ targeted_by_antibiotic antibiotic A40926 [Antibiotic]
+ cell wall component targeted by antibiotic
+ targeted_by_antibiotic ristocetin [Antibiotic]
+ targeted_by_antibiotic avoparcin [Antibiotic]

Kim SJ, et al. 2008. J Mol Biol 377(1): 281-293. Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. (PMID 18258256)