chloroeremomycin [Antibiotic]

Download Sequences


Accession ARO:3000184
DefinitionChloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors.
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
1 ontology terms | Show
+ acyl-D-alanyl-D-alanine targeted_by_drug
Publications

van Wageningen AM, et al. 1998. Chem Biol 5(3): 155-162. Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. (PMID 9545426)

Chen H, et al. 2000. Proc Natl Acad Sci U S A 97(22): 11942-11947. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. (PMID 11035791)

Shiozawa H, et al. 2002. J Am Chem Soc 124(15): 3914-3919. Cooperative binding interactions of glycopeptide antibiotics. (PMID 11942828)