Accession | ARO:3000184 |
Definition | Chloroeremomycin is a vancomycin-like glycopeptide, with three sugars instead of two in vancomycin and balhimycin. Chloroeremomycin dimerizes and binds to the terminus of peptidoglycan precursors. |
Drug Class | glycopeptide antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + glycopeptide antibiotic [Drug Class] |
Sub-Term(s) | 1 ontology terms | Show + acyl-D-alanyl-D-alanine targeted_by_antibiotic |
Publications | van Wageningen AM, et al. 1998. Chem Biol 5(3): 155-162. Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic. (PMID 9545426) Chen H, et al. 2000. Proc Natl Acad Sci U S A 97(22): 11942-11947. Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis. (PMID 11035791) Shiozawa H, et al. 2002. J Am Chem Soc 124(15): 3914-3919. Cooperative binding interactions of glycopeptide antibiotics. (PMID 11942828) |