oritavancin [Antibiotic]

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Accession ARO:3000189
DefinitionOritavancin is a semi-synthetic derivative of chloroeremomycin, a vancomycin-like glycopeptide. Oritavancin inhibits both transglycosylation and transpeptidation, by binding both the D-Ala-D-Ala and pentaglycine bridge segments of peptidoglycan to inhibit cell wall formation.
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ pentaglycyl bridge targeted_by_antibiotic
+ acyl-D-alanyl-D-alanine targeted_by_antibiotic

Mercier RC and Hrebickova L. 2005. Expert Rev Anti Infect Ther 3(3): 325-332. Oritavancin: a new avenue for resistant Gram-positive bacteria. (PMID 15954849)

Kim SJ, et al. 2008. J Mol Biol 377(1): 281-293. Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. (PMID 18258256)

Tatarkiewicz J, et al. 2016. Arch Med Sci 12(6):1327-1336 New agents approved for treatment of acute staphylococcal skin infections. (PMID 27904526)