| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:0000029 |
| Synonym(s) | targocid teichomycin |
| Definition | Teicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation. |
| SMILES | CC(=O)N[C@@H]1[C@H](Oc2c3cc4cc2Oc2ccc(cc2Cl)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2NC(C)=O)[C@@H]2NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H]4NC(=O)[C@@H](Cc5ccc(c(Cl)c5)O3)NC(=O)[C@H](N)c3ccc(O)c(c3)Oc3cc(O)cc4c3)c3ccc(O)c(c3)-c3c(O[C@H]4O[C@H](CO)[C@@H](O)[C@@H](O)[C@@H]4O)cc(O)cc3[C@@H](C(=O)O)NC2=O)O[C@@H](CO)[C@@H](O)[C@@H]1O |
| PubChem | 16129712 |
| ChEBI | 29687 |
| CAS | 61036-62-2 |
| ChEMBL | CHEMBL2367892 |
| Drug Class | glycopeptide antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + glycopeptide antibiotic [Drug Class] |
| Sub-Term(s) | 8 ontology terms | Show + acyl-D-alanyl-D-alanine targeted_by_antibiotic + glycopeptide resistance gene cluster VanA confers_resistance_to_antibiotic + cfr(D) confers_resistance_to_antibiotic + glycopeptide resistance gene cluster VanD confers_resistance_to_antibiotic + glycopeptide resistance gene cluster VanI confers_resistance_to_antibiotic + glycopeptide resistance gene cluster VanM confers_resistance_to_antibiotic + glycopeptide resistance gene cluster vanP confers_resistance_to_antibiotic + vanJ confers_resistance_to_antibiotic |
| Publications | Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) Williams AH and Gruneberg RN. 1984. J Antimicrob Chemother 14(5): 441-445. Teicoplanin. (PMID 6239854) Somma S, et al. 1984. Antimicrob Agents Chemother 26(6): 917-923. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. (PMID 6240963) Coronelli C, et al. 1984. J Antibiot (Tokyo) 37(6): 621-626. Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. V. Aromatic constituents. (PMID 6235205) Schaison G, et al. 2000. J Chemother 12(SUPPL 5): 26-33. Teicoplanin in the treatment of serious infection. (PMID 11131961) |
| Curator | Description | Most Recent Edit |
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