teicoplanin [Antibiotic]

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Accession ARO:0000029
Synonym(s)targocid teichomycin
DefinitionTeicoplanin is a glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria. Teicoplanin has a unique acyl-aliphatic chain, and binds to cell wall precursors to inhibit transglycosylation and transpeptidation.
Drug Classglycopeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
3 ontology terms | Show
+ acyl-D-alanyl-D-alanine targeted_by_antibiotic
+ vanJ confers_resistance_to_antibiotic
+ glycopeptide resistance gene cluster VanA confers_resistance_to_antibiotic
Publications

Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116)

Williams AH and Gruneberg RN. 1984. J Antimicrob Chemother 14(5): 441-445. Teicoplanin. (PMID 6239854)

Somma S, et al. 1984. Antimicrob Agents Chemother 26(6): 917-923. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. (PMID 6240963)

Coronelli C, et al. 1984. J Antibiot (Tokyo) 37(6): 621-626. Teicoplanin, antibiotics from Actinoplanes teichomyceticus nov. sp. V. Aromatic constituents. (PMID 6235205)

Schaison G, et al. 2000. J Chemother 12(SUPPL 5): 26-33. Teicoplanin in the treatment of serious infection. (PMID 11131961)