| Accession | ARO:3000253 |
| CARD Short Name | vanD_cluster |
| Definition | Homologous to vanA, contains a D-Ala-D-Lac ligase. This cluster is constitutively expressed in the chromosome due to a dysfunctional D-ala-D-ala ligase and confers moderate resistance to both vancomycin and teicoplanin. Gene orientation: vanRSYHDX. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + confers_resistance_to_antibiotic teicoplanin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
| Sub-Term(s) | 6 ontology terms | Show + vanD part_of + vanH gene in vanD cluster part_of + vanR gene in vanD cluster part_of + vanS gene in vanD cluster part_of + vanY gene in vanD cluster part_of + vanX gene in vanD cluster part_of |
| Publications | Perichon B, et al. 1997. Antimicrob Agents Chemother 41(9): 2016-2018. VanD-type glycopeptide-resistant Enterococcus faecium BM4339. (PMID 9303405) Depardieu F, et al. 2002. Antimicrob Agents Chemother 47(1): 7-18. VanD-type vancomycin-resistant Enterococcus faecium 10/96A. (PMID 12499162) Casadewall B, et al. 2001. J Bacteriol 183(11): 3436-3446. Regulation of expression of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339. (PMID 11344152) Courvalin P. 2005. Clin Infect Dis 42(SUPPL 1): S25-S34. Vancomycin resistance in gram-positive cocci. (PMID 16323116) |
Prevalence of glycopeptide resistance gene cluster VanD among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster VanD
Model Description:
Regulatory: vanR gene in vanD clustervanS gene in vanD cluster
Core: vanDvanH gene in vanD clustervanX gene in vanD cluster
Accessory: vanY gene in vanD cluster