| Accession | ARO:3007187 |
| CARD Short Name | vanP_cluster |
| Definition | This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS. |
| AMR Gene Family | glycopeptide resistance gene cluster |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + restructuring of bacterial cell wall conferring antibiotic resistance + glycopeptide antibiotic [Drug Class] + antibiotic resistance gene cluster, cassette, or operon |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic vancomycin [Antibiotic] + confers_resistance_to_antibiotic teicoplanin [Antibiotic] + glycopeptide resistance gene cluster [AMR Gene Family] |
| Sub-Term(s) | 5 ontology terms | Show + vanH gene in vanP cluster part_of + vanP part_of + vanX gene in vanP cluster part_of + vanR gene in vanP cluster part_of + vanS gene in vanP cluster part_of |
| Publications | Xavier BB, et al. 2021. Euro Surveill 26(36): Novel vancomycin resistance gene cluster in Enterococcus faecium ST1486, Belgium, June 2021. (PMID 34505571) |
Prevalence of glycopeptide resistance gene cluster vanP among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: glycopeptide resistance gene cluster vanP
Model Description: This cluster confers resistance to both vancomycin and teicoplanin by allowing restructuring of peptidoglycan precursors to end in D-Ala-D-Lac. Resistance is acquired after multiple treatments with sub-minimum inhibitory concentrations of vancomycin. Gene orientation: vanHPXRS.
Regulatory: vanR gene in vanP clustervanS gene in vanP cluster
Core: vanH gene in vanP clustervanPvanX gene in vanP cluster